| http://purl.uniprot.org/citations/24590766 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24590766 | http://www.w3.org/2000/01/rdf-schema#comment | "Tyrosine phosphorylation of signaling molecules that mediate B cell activation in response to various stimuli is tightly regulated by protein tyrosine phosphatases (PTPs). PTP1B is a ubiquitously expressed tyrosine phosphatase with well-characterized functions in metabolic signaling pathways. We show here that PTP1B negatively regulates CD40, B cell activating factor receptor (BAFF-R), and TLR4 signaling in B cells. Specifically, PTP1B counteracts p38 mitogen-activated protein kinase (MAPK) activation by directly dephosphorylating Tyr(182) of this kinase. Mice with a B cell-specific PTP1B deficiency show increased T cell-dependent immune responses and elevated total serum IgG. Furthermore, aged animals develop systemic autoimmunity with elevated serum anti-dsDNA, spontaneous germinal centers in the spleen, and deposition of IgG immune complexes and C3 in the kidney. In a clinical setting, we observed that B cells of rheumatoid arthritis patients have significantly reduced PTP1B expression. Our data suggest that PTP1B plays an important role in the control of B cell activation and the maintenance of immunological tolerance."xsd:string |
| http://purl.uniprot.org/citations/24590766 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20131196"xsd:string |
| http://purl.uniprot.org/citations/24590766 | http://purl.uniprot.org/core/author | "Reth M."xsd:string |
| http://purl.uniprot.org/citations/24590766 | http://purl.uniprot.org/core/author | "Taddeo A."xsd:string |
| http://purl.uniprot.org/citations/24590766 | http://purl.uniprot.org/core/author | "Hobeika E."xsd:string |
| http://purl.uniprot.org/citations/24590766 | http://purl.uniprot.org/core/author | "Voll R.E."xsd:string |
| http://purl.uniprot.org/citations/24590766 | http://purl.uniprot.org/core/author | "Medgyesi D."xsd:string |
| http://purl.uniprot.org/citations/24590766 | http://purl.uniprot.org/core/author | "Hiepe F."xsd:string |
| http://purl.uniprot.org/citations/24590766 | http://purl.uniprot.org/core/author | "Kollert F."xsd:string |
| http://purl.uniprot.org/citations/24590766 | http://purl.uniprot.org/core/author | "Biesen R."xsd:string |
| http://purl.uniprot.org/citations/24590766 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24590766 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/24590766 | http://purl.uniprot.org/core/pages | "427-440"xsd:string |
| http://purl.uniprot.org/citations/24590766 | http://purl.uniprot.org/core/title | "The protein tyrosine phosphatase PTP1B is a negative regulator of CD40 and BAFF-R signaling and controls B cell autoimmunity."xsd:string |
| http://purl.uniprot.org/citations/24590766 | http://purl.uniprot.org/core/volume | "211"xsd:string |
| http://purl.uniprot.org/citations/24590766 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24590766 |
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