| http://purl.uniprot.org/citations/24591366 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24591366 | http://www.w3.org/2000/01/rdf-schema#comment | "Thymocytes mature in a series of stages by migrating through specific areas of the thymus and interacting with other cells to receive the necessary developmental signals; however, little is known about the molecular mechanisms governing this migration. We report that murine thymocytes with a knockout mutation in α-PAK (p21-activated kinase)-interacting exchange factor (PIX; Arhgef6), an activator of Rho GTPases, showed greatly increased motility and altered morphology in two-dimensional migration on ICAM-1. αPIX was also required for efficient positive selection, but not negative selection, of thymocytes. TCR signaling was normal in αPix(-) thymocytes, indicating that the effects of αPIX on positive selection are largely independent of TCR signaling. αPix(-) thymocytes also paused less during migration in the thymic cortex, interacted less with ICAM-1 coated beads, and could overcome TCR stop signals, consistent with defective scanning behavior. These results identify αPIX as a regulator of thymocyte migration and subsequent arrest that is linked to positive selection."xsd:string |
| http://purl.uniprot.org/citations/24591366 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1302585"xsd:string |
| http://purl.uniprot.org/citations/24591366 | http://purl.uniprot.org/core/author | "Steiner M."xsd:string |
| http://purl.uniprot.org/citations/24591366 | http://purl.uniprot.org/core/author | "Premont R.T."xsd:string |
| http://purl.uniprot.org/citations/24591366 | http://purl.uniprot.org/core/author | "Fischer K.D."xsd:string |
| http://purl.uniprot.org/citations/24591366 | http://purl.uniprot.org/core/author | "Korthals M."xsd:string |
| http://purl.uniprot.org/citations/24591366 | http://purl.uniprot.org/core/author | "Mamula D."xsd:string |
| http://purl.uniprot.org/citations/24591366 | http://purl.uniprot.org/core/author | "Tedford K."xsd:string |
| http://purl.uniprot.org/citations/24591366 | http://purl.uniprot.org/core/author | "Thomas U."xsd:string |
| http://purl.uniprot.org/citations/24591366 | http://purl.uniprot.org/core/author | "Schilling K."xsd:string |
| http://purl.uniprot.org/citations/24591366 | http://purl.uniprot.org/core/author | "Langnase K."xsd:string |
| http://purl.uniprot.org/citations/24591366 | http://purl.uniprot.org/core/author | "Schluter T."xsd:string |
| http://purl.uniprot.org/citations/24591366 | http://purl.uniprot.org/core/author | "Reichardt P."xsd:string |
| http://purl.uniprot.org/citations/24591366 | http://purl.uniprot.org/core/author | "Gundelfinger E."xsd:string |
| http://purl.uniprot.org/citations/24591366 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24591366 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/24591366 | http://purl.uniprot.org/core/pages | "3228-3238"xsd:string |
| http://purl.uniprot.org/citations/24591366 | http://purl.uniprot.org/core/title | "alphaPIX RhoGEF supports positive selection by restraining migration and promoting arrest of thymocytes."xsd:string |
| http://purl.uniprot.org/citations/24591366 | http://purl.uniprot.org/core/volume | "192"xsd:string |
| http://purl.uniprot.org/citations/24591366 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24591366 |
| http://purl.uniprot.org/citations/24591366 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24591366 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0F4-mappedCitation-24591366 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24591366 |
| http://purl.uniprot.org/uniprot/#_D3Z1I2-mappedCitation-24591366 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24591366 |
| http://purl.uniprot.org/uniprot/#_P0C6B2-mappedCitation-24591366 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24591366 |