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http://purl.uniprot.org/citations/24594058http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/24594058http://www.w3.org/2000/01/rdf-schema#comment"

Background

Neuronal polarization is an essential step of morphogenesis and connectivity in the developing brain. The serine/threonine kinase LKB1 is a key regulator of cell polarity, metabolism, tumorigenesis, and is required for axon formation. It is allosterically regulated by two related and evolutionarily conserved pseudokinases, STe20-Related ADapters (STRADs) α and β. The roles of STRADα and STRADβ in the developing nervous system are not fully defined, nor is it known whether they serve distinct functions.

Results

We find that STRADα is highly spliced and appears to be the primal STRAD paralog. We report that each STRAD is sufficient for axogenesis and promoting cell survival in the developing cortex. We also reveal a reciprocal protein-stabilizing relationship in vivo between LKB1 and STRADα, whereby STRADα specifically maintains LKB1 protein levels via cytoplasmic compartmentalization.

Conclusions

We demonstrate a novel role for STRADβ in axogenesis and also show for the first time in vivo that STRADα, but not STRADβ, is responsible for LKB1 protein stability."xsd:string
http://purl.uniprot.org/citations/24594058http://purl.org/dc/terms/identifier"doi:10.1186/1749-8104-9-5"xsd:string
http://purl.uniprot.org/citations/24594058http://purl.uniprot.org/core/author"Brown A."xsd:string
http://purl.uniprot.org/citations/24594058http://purl.uniprot.org/core/author"Hansen K."xsd:string
http://purl.uniprot.org/citations/24594058http://purl.uniprot.org/core/author"Gaucher E.A."xsd:string
http://purl.uniprot.org/citations/24594058http://purl.uniprot.org/core/author"Clevers H."xsd:string
http://purl.uniprot.org/citations/24594058http://purl.uniprot.org/core/author"Barnes A.P."xsd:string
http://purl.uniprot.org/citations/24594058http://purl.uniprot.org/core/author"Baas A.F."xsd:string
http://purl.uniprot.org/citations/24594058http://purl.uniprot.org/core/author"Smart J.L."xsd:string
http://purl.uniprot.org/citations/24594058http://purl.uniprot.org/core/author"Zhao Z.M."xsd:string
http://purl.uniprot.org/citations/24594058http://purl.uniprot.org/core/author"Reilly G."xsd:string
http://purl.uniprot.org/citations/24594058http://purl.uniprot.org/core/author"Veleva-Rotse B.O."xsd:string
http://purl.uniprot.org/citations/24594058http://purl.uniprot.org/core/author"Edmonds B."xsd:string
http://purl.uniprot.org/citations/24594058http://purl.uniprot.org/core/author"Gardner A.P."xsd:string
http://purl.uniprot.org/citations/24594058http://purl.uniprot.org/core/author"Klug L.R."xsd:string
http://purl.uniprot.org/citations/24594058http://purl.uniprot.org/core/author"Subbiah K."xsd:string
http://purl.uniprot.org/citations/24594058http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/24594058http://purl.uniprot.org/core/name"Neural Dev"xsd:string
http://purl.uniprot.org/citations/24594058http://purl.uniprot.org/core/pages"5"xsd:string
http://purl.uniprot.org/citations/24594058http://purl.uniprot.org/core/title"STRAD pseudokinases regulate axogenesis and LKB1 stability."xsd:string
http://purl.uniprot.org/citations/24594058http://purl.uniprot.org/core/volume"9"xsd:string
http://purl.uniprot.org/citations/24594058http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/24594058
http://purl.uniprot.org/citations/24594058http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/24594058
http://purl.uniprot.org/uniprot/#_A0A087WPS6-mappedCitation-24594058http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24594058
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