| http://purl.uniprot.org/citations/24596420 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24596420 | http://www.w3.org/2000/01/rdf-schema#comment | "Nucleophosmin-mutated acute myeloid leukemia (NPM1mut-AML) patients have a high rate of complete remission (CR) to induction chemotherapy. However, the mechanisms responsible for such effects are unknown. Because miR-10 family members are expressed at high levels in NPM1mut-AML, we evaluated whether these microRNAs could predict chemotherapy response in AML. We found that high baseline miR-10 family expression in 54 untreated cytogenetically heterogeneous AML patients was associated with achieving CR. However, when we included NPM1 mutation status in the multivariable model, there was a significant interaction effect between miR-10a-5p expression and NPM1 mutation status. Similar results were observed when using a second cohort of 183 cytogenetically normal older (age ≥ 60 years) AML patients. Loss- and gain-of-function experiments using miR-10a-5p in cell lines and primary blasts did not demonstrate any effect in apoptosis or cell proliferation at baseline or after chemotherapy. These data support a bystander role for the miR-10 family in NPM1mut-AML."xsd:string |
| http://purl.uniprot.org/citations/24596420 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2013-10-532374"xsd:string |
| http://purl.uniprot.org/citations/24596420 | http://purl.uniprot.org/core/author | "Huang X."xsd:string |
| http://purl.uniprot.org/citations/24596420 | http://purl.uniprot.org/core/author | "Yu X."xsd:string |
| http://purl.uniprot.org/citations/24596420 | http://purl.uniprot.org/core/author | "Volinia S."xsd:string |
| http://purl.uniprot.org/citations/24596420 | http://purl.uniprot.org/core/author | "Ranganathan P."xsd:string |
| http://purl.uniprot.org/citations/24596420 | http://purl.uniprot.org/core/author | "Andreeff M."xsd:string |
| http://purl.uniprot.org/citations/24596420 | http://purl.uniprot.org/core/author | "Croce C.M."xsd:string |
| http://purl.uniprot.org/citations/24596420 | http://purl.uniprot.org/core/author | "Bloomfield C.D."xsd:string |
| http://purl.uniprot.org/citations/24596420 | http://purl.uniprot.org/core/author | "Marcucci G."xsd:string |
| http://purl.uniprot.org/citations/24596420 | http://purl.uniprot.org/core/author | "Geyer S."xsd:string |
| http://purl.uniprot.org/citations/24596420 | http://purl.uniprot.org/core/author | "Kornblau S.M."xsd:string |
| http://purl.uniprot.org/citations/24596420 | http://purl.uniprot.org/core/author | "Garzon R."xsd:string |
| http://purl.uniprot.org/citations/24596420 | http://purl.uniprot.org/core/author | "Havelange V."xsd:string |
| http://purl.uniprot.org/citations/24596420 | http://purl.uniprot.org/core/author | "Nicolet D."xsd:string |
| http://purl.uniprot.org/citations/24596420 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24596420 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/24596420 | http://purl.uniprot.org/core/pages | "2412-2415"xsd:string |
| http://purl.uniprot.org/citations/24596420 | http://purl.uniprot.org/core/title | "Implications of the miR-10 family in chemotherapy response of NPM1-mutated AML."xsd:string |
| http://purl.uniprot.org/citations/24596420 | http://purl.uniprot.org/core/volume | "123"xsd:string |
| http://purl.uniprot.org/citations/24596420 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24596420 |
| http://purl.uniprot.org/citations/24596420 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24596420 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JNH0-mappedCitation-24596420 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24596420 |
| http://purl.uniprot.org/uniprot/#_A0A140VJQ2-mappedCitation-24596420 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24596420 |