| http://purl.uniprot.org/citations/24604355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24604355 | http://www.w3.org/2000/01/rdf-schema#comment | "The cellular prion protein (PrPC) is a highly conserved protein whose exact physiological role remains elusive. In the present study, we investigated age-dependent behavioral abnormalities in PrPC-knockout (Prnp0/0) mice and wild-type (WT) controls. Prnp0/0 mice showed age-dependent behavioral deficits in memory performance, associative learning, basal anxiety, and nest building behavior. Using a hypothesis-free quantitative proteomic investigation, we found that loss of PrPC affected the levels of neurofilament proteins in an age-dependent manner. In order to understand the biochemical basis of these observations, we analyzed the phosphorylation status of neurofilament heavy chain (NF-H). We found a reduction in NF-H phosphorylation in both Prnp0/0 mice and in PrPC-deficient cells. The expression of Fyn and phospho-Fyn, a potential regulator for NF phosphorylation, was associated with PrPC ablation. The number of β-tubulin III-positive neurons in the hippocampus was diminished in Prnp0/0 mice relative to WT mice. These data indicate that PrPC plays an important role in cytoskeletal organization, brain function, and age-related neuroprotection. Our work represents the first direct biochemical link between these proteins and the observed behavioral phenotypes."xsd:string |
| http://purl.uniprot.org/citations/24604355 | http://purl.org/dc/terms/identifier | "doi:10.1007/s12035-014-8655-3"xsd:string |
| http://purl.uniprot.org/citations/24604355 | http://purl.uniprot.org/core/author | "Fischer A."xsd:string |
| http://purl.uniprot.org/citations/24604355 | http://purl.uniprot.org/core/author | "Schmitz M."xsd:string |
| http://purl.uniprot.org/citations/24604355 | http://purl.uniprot.org/core/author | "Requena J.R."xsd:string |
| http://purl.uniprot.org/citations/24604355 | http://purl.uniprot.org/core/author | "Silva C.J."xsd:string |
| http://purl.uniprot.org/citations/24604355 | http://purl.uniprot.org/core/author | "Wrede A."xsd:string |
| http://purl.uniprot.org/citations/24604355 | http://purl.uniprot.org/core/author | "Zerr I."xsd:string |
| http://purl.uniprot.org/citations/24604355 | http://purl.uniprot.org/core/author | "Korth C."xsd:string |
| http://purl.uniprot.org/citations/24604355 | http://purl.uniprot.org/core/author | "Govindarajan N."xsd:string |
| http://purl.uniprot.org/citations/24604355 | http://purl.uniprot.org/core/author | "Schulz-Schaeffer W.J."xsd:string |
| http://purl.uniprot.org/citations/24604355 | http://purl.uniprot.org/core/author | "Onisko B."xsd:string |
| http://purl.uniprot.org/citations/24604355 | http://purl.uniprot.org/core/author | "Ottis P."xsd:string |
| http://purl.uniprot.org/citations/24604355 | http://purl.uniprot.org/core/author | "Greis C."xsd:string |
| http://purl.uniprot.org/citations/24604355 | http://purl.uniprot.org/core/author | "Koppe K."xsd:string |
| http://purl.uniprot.org/citations/24604355 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24604355 | http://purl.uniprot.org/core/name | "Mol Neurobiol"xsd:string |
| http://purl.uniprot.org/citations/24604355 | http://purl.uniprot.org/core/pages | "923-936"xsd:string |
| http://purl.uniprot.org/citations/24604355 | http://purl.uniprot.org/core/title | "Loss of prion protein leads to age-dependent behavioral abnormalities and changes in cytoskeletal protein expression."xsd:string |
| http://purl.uniprot.org/citations/24604355 | http://purl.uniprot.org/core/volume | "50"xsd:string |
| http://purl.uniprot.org/citations/24604355 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24604355 |
| http://purl.uniprot.org/citations/24604355 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24604355 |
| http://purl.uniprot.org/uniprot/#_Q3TZI7-mappedCitation-24604355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24604355 |
| http://purl.uniprot.org/uniprot/#_Q3UG89-mappedCitation-24604355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24604355 |