Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/24605680http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/24605680http://www.w3.org/2000/01/rdf-schema#comment"

Aim

Study cytokine-mediated immune response in mice vaccinated with Pseudomonas aeruginosa recombinant antigen preparations.

Materials and methods

Cytokine-mediated immune response was studied in mice vaccinated with membrane recombinant proteins OprF, OprL, a hybrid recombinant protein OprF-I consisting of sequences of OprF and OprI proteins and a recombinant atoxic form of exotoxin A with a deletion of 106 amino acid sequences (recombinant anatoxin - aTox) of P. aeruginosa.

Results

An induction of a wide specter of studied cytokines was detected in the mice. The highest level was observed for IL-1 and IL-6 after administration of recombinant proteins OprL, OprF, OprF-1, aTox. OprF-I actively stimulated production of IL-2 that is a factor of growth and differentiation of lymphocytes, natural killers and cytotoxic lymphocytes; as well as IL-5, IL-O10, TNF-alpha and IFN-gamma. Recombinant protein OprF-I facilitated induction of IL-6, IL-17, TNF-alpha and IFN-gamma, whereas aTox - expression of IL-1, IL-2, IFN-gamma. Recombinant protein OprL induced IL-17 synthesis to the most extent and TNF-alpha and IL-10 - moderately.

Conclusion

The P. aeruginosa recombinant proteins obtained during intraperitoneal administration to mice facilitated formation of immune response with the direction of induction in both Thl and Th2 pathways."xsd:string
http://purl.uniprot.org/citations/24605680http://purl.uniprot.org/core/author"Mikhailova N.A."xsd:string
http://purl.uniprot.org/citations/24605680http://purl.uniprot.org/core/author"Akhmatova N.K."xsd:string
http://purl.uniprot.org/citations/24605680http://purl.uniprot.org/core/author"Geiderova L.A."xsd:string
http://purl.uniprot.org/citations/24605680http://purl.uniprot.org/core/author"Soldatenkova A.V."xsd:string
http://purl.uniprot.org/citations/24605680http://purl.uniprot.org/core/date"2013"xsd:gYear
http://purl.uniprot.org/citations/24605680http://purl.uniprot.org/core/name"Zh Mikrobiol Epidemiol Immunobiol"xsd:string
http://purl.uniprot.org/citations/24605680http://purl.uniprot.org/core/pages"80-87"xsd:string
http://purl.uniprot.org/citations/24605680http://purl.uniprot.org/core/title"[Pseudomonas aeruginosa recombinant proteins: effect on mice cytokine profile]."xsd:string
http://purl.uniprot.org/citations/24605680http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/24605680
http://purl.uniprot.org/citations/24605680http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/24605680
http://purl.uniprot.org/uniprot/#_A0A0G2JGF4-mappedCitation-24605680http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24605680
http://purl.uniprot.org/uniprot/#_Q0PMN1-mappedCitation-24605680http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24605680
http://purl.uniprot.org/uniprot/#_Q0X0E6-mappedCitation-24605680http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24605680
http://purl.uniprot.org/uniprot/#_A0A7R8C347-mappedCitation-24605680http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24605680
http://purl.uniprot.org/uniprot/#_A0A7R8GUQ3-mappedCitation-24605680http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24605680
http://purl.uniprot.org/uniprot/#_A0A0R4J210-mappedCitation-24605680http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24605680
http://purl.uniprot.org/uniprot/#_A0A0U5J4W4-mappedCitation-24605680http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24605680
http://purl.uniprot.org/uniprot/#_A2RTD1-mappedCitation-24605680http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24605680
http://purl.uniprot.org/uniprot/#_A3RL32-mappedCitation-24605680http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24605680
http://purl.uniprot.org/uniprot/#_C4NUL9-mappedCitation-24605680http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24605680
http://purl.uniprot.org/uniprot/#_C4NUM1-mappedCitation-24605680http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24605680
http://purl.uniprot.org/uniprot/#_Q62349-mappedCitation-24605680http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24605680
http://purl.uniprot.org/uniprot/#_P01580-mappedCitation-24605680http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24605680
▶