| http://purl.uniprot.org/citations/24606900 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24606900 | http://www.w3.org/2000/01/rdf-schema#comment | "Healthy aging depends on removal of damaged cellular material that is in part mediated by autophagy. The nutritional status of cells affects both aging and autophagy through as-yet-elusive metabolic circuitries. Here, we show that nucleocytosolic acetyl-coenzyme A (AcCoA) production is a metabolic repressor of autophagy during aging in yeast. Blocking the mitochondrial route to AcCoA by deletion of the CoA-transferase ACH1 caused cytosolic accumulation of the AcCoA precursor acetate. This led to hyperactivation of nucleocytosolic AcCoA-synthetase Acs2p, triggering histone acetylation, repression of autophagy genes, and an age-dependent defect in autophagic flux, culminating in a reduced lifespan. Inhibition of nutrient signaling failed to restore, while simultaneous knockdown of ACS2 reinstated, autophagy and survival of ach1 mutant. Brain-specific knockdown of Drosophila AcCoA synthetase was sufficient to enhance autophagic protein clearance and prolong lifespan. Since AcCoA integrates various nutrition pathways, our findings may explain diet-dependent lifespan and autophagy regulation."xsd:string |
| http://purl.uniprot.org/citations/24606900 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2014.02.010"xsd:string |
| http://purl.uniprot.org/citations/24606900 | http://purl.uniprot.org/core/author | "Marino G."xsd:string |
| http://purl.uniprot.org/citations/24606900 | http://purl.uniprot.org/core/author | "Moser C."xsd:string |
| http://purl.uniprot.org/citations/24606900 | http://purl.uniprot.org/core/author | "Schroeder S."xsd:string |
| http://purl.uniprot.org/citations/24606900 | http://purl.uniprot.org/core/author | "Juhasz G."xsd:string |
| http://purl.uniprot.org/citations/24606900 | http://purl.uniprot.org/core/author | "Kroemer G."xsd:string |
| http://purl.uniprot.org/citations/24606900 | http://purl.uniprot.org/core/author | "Zimmermann A."xsd:string |
| http://purl.uniprot.org/citations/24606900 | http://purl.uniprot.org/core/author | "Ring J."xsd:string |
| http://purl.uniprot.org/citations/24606900 | http://purl.uniprot.org/core/author | "Madeo F."xsd:string |
| http://purl.uniprot.org/citations/24606900 | http://purl.uniprot.org/core/author | "Sigrist S.J."xsd:string |
| http://purl.uniprot.org/citations/24606900 | http://purl.uniprot.org/core/author | "Dengjel J."xsd:string |
| http://purl.uniprot.org/citations/24606900 | http://purl.uniprot.org/core/author | "Buttner S."xsd:string |
| http://purl.uniprot.org/citations/24606900 | http://purl.uniprot.org/core/author | "Carmona-Gutierrez D."xsd:string |
| http://purl.uniprot.org/citations/24606900 | http://purl.uniprot.org/core/author | "Eisenberg T."xsd:string |
| http://purl.uniprot.org/citations/24606900 | http://purl.uniprot.org/core/author | "Frohlich K.U."xsd:string |
| http://purl.uniprot.org/citations/24606900 | http://purl.uniprot.org/core/author | "Leeb T."xsd:string |
| http://purl.uniprot.org/citations/24606900 | http://purl.uniprot.org/core/author | "Pieber T.R."xsd:string |
| http://purl.uniprot.org/citations/24606900 | http://purl.uniprot.org/core/author | "Moustafa T."xsd:string |
| http://purl.uniprot.org/citations/24606900 | http://purl.uniprot.org/core/author | "Pendl T."xsd:string |
| http://purl.uniprot.org/citations/24606900 | http://purl.uniprot.org/core/author | "Sedej S."xsd:string |
| http://purl.uniprot.org/citations/24606900 | http://purl.uniprot.org/core/author | "Ruckenstuhl C."xsd:string |
| http://purl.uniprot.org/citations/24606900 | http://purl.uniprot.org/core/author | "Bhukel A."xsd:string |
| http://purl.uniprot.org/citations/24606900 | http://purl.uniprot.org/core/author | "Reichelt W."xsd:string |