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http://purl.uniprot.org/citations/24607481 | http://www.w3.org/2000/01/rdf-schema#comment | "In this study, we demonstrate that the 7SK small nuclear ribonucleoprotein (snRNP) complex is recruited to the HIV-1 promoter via newly-synthesized HIV-1 nascent transcripts (short transcripts) in an hnRNP A1-dependent manner and negatively regulates viral transcript elongation. Our deep-sequence analysis showed these short transcripts were mainly arrested at approximately +50 to +70 nucleotides from the transcriptional start site in the U1 cells, an HIV-1 latent model. TNF-α treatment promptly disrupted the 7SK snRNP complex on the nascent transcripts and viral elongated transcripts were increased. This report provides insight into how 7SK snRNP complex is recruited to HIV-1 promoter in the absence of Tat."xsd:string |
http://purl.uniprot.org/citations/24607481 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2014.01.067"xsd:string |
http://purl.uniprot.org/citations/24607481 | http://purl.uniprot.org/core/author | "Suzuki Y."xsd:string |
http://purl.uniprot.org/citations/24607481 | http://purl.uniprot.org/core/author | "Iba H."xsd:string |
http://purl.uniprot.org/citations/24607481 | http://purl.uniprot.org/core/author | "Mizutani T."xsd:string |
http://purl.uniprot.org/citations/24607481 | http://purl.uniprot.org/core/author | "Ishizaka A."xsd:string |
http://purl.uniprot.org/citations/24607481 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
http://purl.uniprot.org/citations/24607481 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
http://purl.uniprot.org/citations/24607481 | http://purl.uniprot.org/core/pages | "1630-1636"xsd:string |
http://purl.uniprot.org/citations/24607481 | http://purl.uniprot.org/core/title | "7SK small nuclear ribonucleoprotein complex is recruited to the HIV-1 promoter via short viral transcripts."xsd:string |
http://purl.uniprot.org/citations/24607481 | http://purl.uniprot.org/core/volume | "588"xsd:string |
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