| http://purl.uniprot.org/citations/24613476 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24613476 | http://www.w3.org/2000/01/rdf-schema#comment | "Thymosin β4 (Tβ4) is a highly conserved peptide with immunomodulatory properties. In this research we investigated the effects of Tβ4 on the bleomycin-induced lung damage in CD-1 mice and the changes in the number of IL-17-producing cells as well as the IL-17 expression in the lung. Male CD-1 mice were treated with bleomycin (1mg/kg) in the absence or the presence of Tβ4 (6mg/kg delivered intra-peritoneally on the day of bleomycin treatment and for 2 additional doses). After sacrifice one week later, lung histology, measurement of collagen content of the lung, Broncho Alveolar Lavage Fluid (BALF) analysis, evaluation of IL17-producing cells in the blood as well as RT-PCR and IHC in the lung tissue were performed. As expected, bleomycin-induced inflammation and lung damage were substantially reduced by Tβ4 treatment in CD-1 mice, as shown by the significant reduction of (i) leukocytes in BALF, (ii) histological evidence of the lung damage, and (iii) total collagen content in the lung. Importantly, the bleomycin-induced increase in the number of IL17-producing cells in the blood was significantly blocked by Tβ4. Accordingly, IHC and RT-PCR results demonstrated that Tβ4 substantially inhibited bleomycin-induced IL-17 over-expression in the lung tissue. This is the first report showing that a decreased amount of IL17-producing cells and inhibited IL-17 expression in the lung with Tβ4 treatment correlate with its anti-inflammatory and anti-fibrotic effects."xsd:string |
| http://purl.uniprot.org/citations/24613476 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.imbio.2014.02.001"xsd:string |
| http://purl.uniprot.org/citations/24613476 | http://purl.uniprot.org/core/author | "Conte E."xsd:string |
| http://purl.uniprot.org/citations/24613476 | http://purl.uniprot.org/core/author | "Esposito E."xsd:string |
| http://purl.uniprot.org/citations/24613476 | http://purl.uniprot.org/core/author | "Cuzzocrea S."xsd:string |
| http://purl.uniprot.org/citations/24613476 | http://purl.uniprot.org/core/author | "Genovese T."xsd:string |
| http://purl.uniprot.org/citations/24613476 | http://purl.uniprot.org/core/author | "Gili E."xsd:string |
| http://purl.uniprot.org/citations/24613476 | http://purl.uniprot.org/core/author | "Vancheri C."xsd:string |
| http://purl.uniprot.org/citations/24613476 | http://purl.uniprot.org/core/author | "Fagone E."xsd:string |
| http://purl.uniprot.org/citations/24613476 | http://purl.uniprot.org/core/author | "Fruciano M."xsd:string |
| http://purl.uniprot.org/citations/24613476 | http://purl.uniprot.org/core/author | "Iemmolo M."xsd:string |
| http://purl.uniprot.org/citations/24613476 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24613476 | http://purl.uniprot.org/core/name | "Immunobiology"xsd:string |
| http://purl.uniprot.org/citations/24613476 | http://purl.uniprot.org/core/pages | "425-431"xsd:string |
| http://purl.uniprot.org/citations/24613476 | http://purl.uniprot.org/core/title | "Thymosin beta4 reduces IL-17-producing cells and IL-17 expression, and protects lungs from damage in bleomycin-treated mice."xsd:string |
| http://purl.uniprot.org/citations/24613476 | http://purl.uniprot.org/core/volume | "219"xsd:string |
| http://purl.uniprot.org/citations/24613476 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24613476 |
| http://purl.uniprot.org/citations/24613476 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24613476 |
| http://purl.uniprot.org/uniprot/#_P20065-mappedCitation-24613476 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24613476 |
| http://purl.uniprot.org/uniprot/#_Q6ZWX2-mappedCitation-24613476 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24613476 |
| http://purl.uniprot.org/uniprot/Q6ZWX2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24613476 |
| http://purl.uniprot.org/uniprot/P20065 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24613476 |