| http://purl.uniprot.org/citations/24613930 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24613930 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24613930 | http://www.w3.org/2000/01/rdf-schema#comment | "Thyroid cancer is a common endocrine malignancy that encompasses well-differentiated as well as dedifferentiated cancer types. The latter tumors have high mortality and lack effective therapies. Using a paired-end RNA-sequencing approach, we report the discovery of rearrangements involving the anaplastic lymphoma kinase (ALK) gene in thyroid cancer. The most common of these involves a fusion between ALK and the striatin (STRN) gene, which is the result of a complex rearrangement involving the short arm of chromosome 2. STRN-ALK leads to constitutive activation of ALK kinase via dimerization mediated by the coiled-coil domain of STRN and to a kinase-dependent, thyroid-stimulating hormone-independent proliferation of thyroid cells. Moreover, expression of STRN-ALK transforms cells in vitro and induces tumor formation in nude mice. The kinase activity of STRN-ALK and the ALK-induced cell growth can be blocked by the ALK inhibitors crizotinib and TAE684. In addition to well-differentiated papillary cancer, STRN-ALK was found with a higher prevalence in poorly differentiated and anaplastic thyroid cancers, and it did not overlap with other known driver mutations in these tumors. Our data demonstrate that STRN-ALK fusion occurs in a subset of patients with highly aggressive types of thyroid cancer and provide initial evidence suggesting that it may represent a therapeutic target for these patients."xsd:string |
| http://purl.uniprot.org/citations/24613930 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1321937111"xsd:string |
| http://purl.uniprot.org/citations/24613930 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1321937111"xsd:string |
| http://purl.uniprot.org/citations/24613930 | http://purl.uniprot.org/core/author | "Luo J."xsd:string |
| http://purl.uniprot.org/citations/24613930 | http://purl.uniprot.org/core/author | "Luo J."xsd:string |
| http://purl.uniprot.org/citations/24613930 | http://purl.uniprot.org/core/author | "Liu P."xsd:string |
| http://purl.uniprot.org/citations/24613930 | http://purl.uniprot.org/core/author | "Liu P."xsd:string |
| http://purl.uniprot.org/citations/24613930 | http://purl.uniprot.org/core/author | "Kelly L.M."xsd:string |
| http://purl.uniprot.org/citations/24613930 | http://purl.uniprot.org/core/author | "Kelly L.M."xsd:string |
| http://purl.uniprot.org/citations/24613930 | http://purl.uniprot.org/core/author | "Ferris R.L."xsd:string |
| http://purl.uniprot.org/citations/24613930 | http://purl.uniprot.org/core/author | "Ferris R.L."xsd:string |
| http://purl.uniprot.org/citations/24613930 | http://purl.uniprot.org/core/author | "Trivedi S."xsd:string |
| http://purl.uniprot.org/citations/24613930 | http://purl.uniprot.org/core/author | "Trivedi S."xsd:string |
| http://purl.uniprot.org/citations/24613930 | http://purl.uniprot.org/core/author | "Altschuler D.L."xsd:string |
| http://purl.uniprot.org/citations/24613930 | http://purl.uniprot.org/core/author | "Altschuler D.L."xsd:string |
| http://purl.uniprot.org/citations/24613930 | http://purl.uniprot.org/core/author | "Gandhi M."xsd:string |
| http://purl.uniprot.org/citations/24613930 | http://purl.uniprot.org/core/author | "Gandhi M."xsd:string |
| http://purl.uniprot.org/citations/24613930 | http://purl.uniprot.org/core/author | "Nikiforov Y.E."xsd:string |
| http://purl.uniprot.org/citations/24613930 | http://purl.uniprot.org/core/author | "Nikiforov Y.E."xsd:string |
| http://purl.uniprot.org/citations/24613930 | http://purl.uniprot.org/core/author | "Nikiforova M.N."xsd:string |
| http://purl.uniprot.org/citations/24613930 | http://purl.uniprot.org/core/author | "Nikiforova M.N."xsd:string |
| http://purl.uniprot.org/citations/24613930 | http://purl.uniprot.org/core/author | "Yu Y.P."xsd:string |
| http://purl.uniprot.org/citations/24613930 | http://purl.uniprot.org/core/author | "Yu Y.P."xsd:string |