| http://purl.uniprot.org/citations/24614691 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24614691 | http://www.w3.org/2000/01/rdf-schema#comment | "Serotonin (5-HT) receptors of type 6 (5-HT6R) play important roles in mood, psychosis, and eating disorders. Recently, a growing number of studies support the use of 5-HT6R-targeting compounds as promising drug candidates for treating cognitive dysfunction associated with Alzheimer's disease. However, the mechanistic linkage between 5-HT6R and such functions remains poorly understood. By using yeast two-hybrid, GST pull-down, and co-immunoprecipitation assays, here we show that human 5-HT6R interacts with the light chain 1 (LC1) subunit of MAP1B protein (MAP1B-LC1), a classical microtubule-associated protein highly expressed in the brain. Functionally, we have found that expression of MAP1B-LC1 regulates serotonin signaling in a receptor subtype-specific manner, specifically controlling the activities of 5-HT6R, but not those of 5-HT4R and 5-HT7R. In addition, we have demonstrated that MAP1B-LC1 increases the surface expression of 5-HT6R and decreases its endocytosis, suggesting that MAP1B-LC1 is involved in the desensitization and trafficking of 5-HT6R via a direct interaction. Together, we suggest that signal transduction pathways downstream of 5-HT6R are regulated by MAP1B, which might play a role in 5-HT6R-mediated signaling in the brain."xsd:string |
| http://purl.uniprot.org/citations/24614691 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0091402"xsd:string |
| http://purl.uniprot.org/citations/24614691 | http://purl.uniprot.org/core/author | "Kim S.H."xsd:string |
| http://purl.uniprot.org/citations/24614691 | http://purl.uniprot.org/core/author | "Kim D.H."xsd:string |
| http://purl.uniprot.org/citations/24614691 | http://purl.uniprot.org/core/author | "Lee K.H."xsd:string |
| http://purl.uniprot.org/citations/24614691 | http://purl.uniprot.org/core/author | "Chung K.C."xsd:string |
| http://purl.uniprot.org/citations/24614691 | http://purl.uniprot.org/core/author | "Hur E.M."xsd:string |
| http://purl.uniprot.org/citations/24614691 | http://purl.uniprot.org/core/author | "Rhim H."xsd:string |
| http://purl.uniprot.org/citations/24614691 | http://purl.uniprot.org/core/author | "Im S.K."xsd:string |
| http://purl.uniprot.org/citations/24614691 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24614691 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/24614691 | http://purl.uniprot.org/core/pages | "e91402"xsd:string |
| http://purl.uniprot.org/citations/24614691 | http://purl.uniprot.org/core/title | "Direct interaction and functional coupling between human 5-HT6 receptor and the light chain 1 subunit of the microtubule-associated protein 1B (MAP1B-LC1)."xsd:string |
| http://purl.uniprot.org/citations/24614691 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/24614691 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24614691 |
| http://purl.uniprot.org/citations/24614691 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24614691 |
| http://purl.uniprot.org/uniprot/#_A0A8I5ZWW4-mappedCitation-24614691 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24614691 |
| http://purl.uniprot.org/uniprot/#_A0A8L2QXZ5-mappedCitation-24614691 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24614691 |
| http://purl.uniprot.org/uniprot/#_A5D6X1-mappedCitation-24614691 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24614691 |
| http://purl.uniprot.org/uniprot/#_A5D8X6-mappedCitation-24614691 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24614691 |
| http://purl.uniprot.org/uniprot/#_A0A8I5ZMJ9-mappedCitation-24614691 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24614691 |
| http://purl.uniprot.org/uniprot/#_B3VRB0-mappedCitation-24614691 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24614691 |
| http://purl.uniprot.org/uniprot/#_B3VRB5-mappedCitation-24614691 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24614691 |
| http://purl.uniprot.org/uniprot/#_B3VRC0-mappedCitation-24614691 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24614691 |