| http://purl.uniprot.org/citations/24614758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24614758 | http://www.w3.org/2000/01/rdf-schema#comment | "Cellular proliferation in response to mitogenic stimuli is negatively regulated by the Cip/Kip and the Ink4 families of cyclin-dependent kinase (CDK) inhibitors. Several of these proteins are elevated in anergic T cells, suggesting a potential role in the induction or maintenance of tolerance. Our previous studies showed that p27kip1 is required for the induction of T cell anergy and transplantation tolerance by costimulatory blockade, but a role for Ink4 proteins in these processes has not been established. Here we show that CD4+ T cells from mice genetically deficient for p18ink4c divide more rapidly than wild-type cells in response to antigenic, costimulatory and growth factor signals. However, this gain of proliferative function was accompanied by a moderate increase in the rate of cell death, and was accompanied by an overall defect in the generation of alloreactive IFNγ-producing effector cells. Consistent with this, p18ink4c-deficient T cells were unable to induce graft-vs-host disease in vivo, and p18ink4c deficiency cooperated with costimulatory blockade to significantly increase the survival of fully mismatched allografts in a cardiac transplantation model. While both p18ink4c and p27kip1 act to restrict T cell proliferation, p18ink4c exerts an opposite effect from p27kip1 on alloimmunity and organ transplant rejection, most likely by sustaining T cell survival and the development of effector function. Our studies point to additional important links between the cell cycle machinery and the processes of T cell differentiation, survival and tolerance."xsd:string |
| http://purl.uniprot.org/citations/24614758 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0091587"xsd:string |
| http://purl.uniprot.org/citations/24614758 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/24614758 | http://purl.uniprot.org/core/author | "Hancock W.W."xsd:string |
| http://purl.uniprot.org/citations/24614758 | http://purl.uniprot.org/core/author | "Wells A.D."xsd:string |
| http://purl.uniprot.org/citations/24614758 | http://purl.uniprot.org/core/author | "Chunder N."xsd:string |
| http://purl.uniprot.org/citations/24614758 | http://purl.uniprot.org/core/author | "Rowell E.A."xsd:string |
| http://purl.uniprot.org/citations/24614758 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24614758 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/24614758 | http://purl.uniprot.org/core/pages | "e91587"xsd:string |
| http://purl.uniprot.org/citations/24614758 | http://purl.uniprot.org/core/title | "Regulation of T cell differentiation and alloimmunity by the cyclin-dependent kinase inhibitor p18ink4c."xsd:string |
| http://purl.uniprot.org/citations/24614758 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/24614758 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24614758 |
| http://purl.uniprot.org/citations/24614758 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24614758 |
| http://purl.uniprot.org/uniprot/#_Q60772-mappedCitation-24614758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24614758 |
| http://purl.uniprot.org/uniprot/#_Q3U054-mappedCitation-24614758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24614758 |
| http://purl.uniprot.org/uniprot/#_Q9D153-mappedCitation-24614758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24614758 |
| http://purl.uniprot.org/uniprot/Q60772 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24614758 |
| http://purl.uniprot.org/uniprot/Q3U054 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24614758 |
| http://purl.uniprot.org/uniprot/Q9D153 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24614758 |