| http://purl.uniprot.org/citations/24614941 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24614941 | http://www.w3.org/2000/01/rdf-schema#comment | "The earliest HSCs are derived from haemogenic endothelium via endothelial-to-haematopoietic transition during vertebrate embryogenesis; however, the underlying mechanism is largely unclear. Here we show that interplay of Smad1/5 and ERK signalling is essential for haemogenic endothelium-based HSC emergence. Smad1/5 directly inhibits erk expression through recruiting HDAC1 to and inducing de-acetylation of the erk promoter in endothelial cells. Over-activated ERK signalling conferred by inhibition of Smad1/5 promotes the arterial endothelial cell fate and constitutively strengthens the tight junction between endothelial cells, thereby repressing the specification of haemogenic endothelium and the following endothelial-to-haematopoietic transition process. These findings provide new insights into the in vitro generation of transplantable HSCs for potential clinical applications."xsd:string |
| http://purl.uniprot.org/citations/24614941 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms4431"xsd:string |
| http://purl.uniprot.org/citations/24614941 | http://purl.uniprot.org/core/author | "Gao Y."xsd:string |
| http://purl.uniprot.org/citations/24614941 | http://purl.uniprot.org/core/author | "Liu F."xsd:string |
| http://purl.uniprot.org/citations/24614941 | http://purl.uniprot.org/core/author | "Meng A."xsd:string |
| http://purl.uniprot.org/citations/24614941 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/24614941 | http://purl.uniprot.org/core/author | "Yang X."xsd:string |
| http://purl.uniprot.org/citations/24614941 | http://purl.uniprot.org/core/author | "Zhang C."xsd:string |
| http://purl.uniprot.org/citations/24614941 | http://purl.uniprot.org/core/author | "He Q."xsd:string |
| http://purl.uniprot.org/citations/24614941 | http://purl.uniprot.org/core/author | "Lv J."xsd:string |
| http://purl.uniprot.org/citations/24614941 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24614941 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/24614941 | http://purl.uniprot.org/core/pages | "3431"xsd:string |
| http://purl.uniprot.org/citations/24614941 | http://purl.uniprot.org/core/title | "Inhibition of endothelial ERK signalling by Smad1/5 is essential for haematopoietic stem cell emergence."xsd:string |
| http://purl.uniprot.org/citations/24614941 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/24614941 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24614941 |
| http://purl.uniprot.org/citations/24614941 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24614941 |
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