| http://purl.uniprot.org/citations/24615015 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24615015 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24615015 | http://www.w3.org/2000/01/rdf-schema#comment | "Proper cell growth is a prerequisite for maintaining repeated cell divisions. Cells need to translate information about intracellular nutrient availability and growth cues from energy-sensing organs into growth-promoting processes, such as sufficient supply with ribosomes for protein synthesis. Mutations in the mushroom body miniature (mbm) gene impair proliferation of neural progenitor cells (neuroblasts) in the central brain of Drosophila melanogaster. Yet the molecular function of Mbm has so far been unknown. Here we show that mbm does not affect the molecular machinery controlling asymmetric cell division of neuroblasts but instead decreases their cell size. Mbm is a nucleolar protein required for small ribosomal subunit biogenesis in neuroblasts. Accordingly, levels of protein synthesis are reduced in mbm neuroblasts. Mbm expression is transcriptionally regulated by Myc, which, among other functions, relays information from nutrient-dependent signaling pathways to ribosomal gene expression. At the posttranslational level, Mbm becomes phosphorylated by casein kinase 2 (CK2), which has an impact on localization of the protein. We conclude that Mbm is a new part of the Myc target network involved in ribosome biogenesis, which, together with CK2-mediated signals, enables neuroblasts to synthesize sufficient amounts of proteins required for proper cell growth."xsd:string |
| http://purl.uniprot.org/citations/24615015 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00658-13"xsd:string |
| http://purl.uniprot.org/citations/24615015 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00658-13"xsd:string |
| http://purl.uniprot.org/citations/24615015 | http://purl.uniprot.org/core/author | "Raabe T."xsd:string |
| http://purl.uniprot.org/citations/24615015 | http://purl.uniprot.org/core/author | "Raabe T."xsd:string |
| http://purl.uniprot.org/citations/24615015 | http://purl.uniprot.org/core/author | "Gallant P."xsd:string |
| http://purl.uniprot.org/citations/24615015 | http://purl.uniprot.org/core/author | "Gallant P."xsd:string |
| http://purl.uniprot.org/citations/24615015 | http://purl.uniprot.org/core/author | "Pfannstiel J."xsd:string |
| http://purl.uniprot.org/citations/24615015 | http://purl.uniprot.org/core/author | "Pfannstiel J."xsd:string |
| http://purl.uniprot.org/citations/24615015 | http://purl.uniprot.org/core/author | "Herter E.K."xsd:string |
| http://purl.uniprot.org/citations/24615015 | http://purl.uniprot.org/core/author | "Herter E.K."xsd:string |
| http://purl.uniprot.org/citations/24615015 | http://purl.uniprot.org/core/author | "Hovhanyan A."xsd:string |
| http://purl.uniprot.org/citations/24615015 | http://purl.uniprot.org/core/author | "Hovhanyan A."xsd:string |
| http://purl.uniprot.org/citations/24615015 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24615015 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24615015 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/24615015 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/24615015 | http://purl.uniprot.org/core/pages | "1878-1891"xsd:string |
| http://purl.uniprot.org/citations/24615015 | http://purl.uniprot.org/core/pages | "1878-1891"xsd:string |
| http://purl.uniprot.org/citations/24615015 | http://purl.uniprot.org/core/title | "Drosophila mbm is a nucleolar myc and casein kinase 2 target required for ribosome biogenesis and cell growth of central brain neuroblasts."xsd:string |
| http://purl.uniprot.org/citations/24615015 | http://purl.uniprot.org/core/title | "Drosophila mbm is a nucleolar myc and casein kinase 2 target required for ribosome biogenesis and cell growth of central brain neuroblasts."xsd:string |
| http://purl.uniprot.org/citations/24615015 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/24615015 | http://purl.uniprot.org/core/volume | "34"xsd:string |