| http://purl.uniprot.org/citations/24615024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24615024 | http://www.w3.org/2000/01/rdf-schema#comment | "We investigated genetic susceptibility to coronary artery disease (CAD) by studying the association of MKL1 gene polymorphisms with CAD in the Chinese Han population. We performed a case-control study with 476 unrelated CAD patients and 325 non-CAD controls. All SNPs were genotyped with a TaqMan SNP genotyping assay. The distribution of MKL1-184C>T gene polymorphism in each group was in Hardy-Weinberg equilibrium. The frequency of the MKL1 T allele in the CAD group was significantly higher than in the control group (38.6 vs 30.8%). After logistic regression models adjusted for CAD risk factors, the risk of CAD among CT genotypes was 1.765 times higher than among the CC genotypes [odds ration (OR) = 1.765, 95% confidence interval (CI) = 1.246-2.5], and for TT genotypes it was 1.806 times higher than for the CC genotypes (OR = 1.806, 95%CI = 1.203-2.71). In summary, genotypes with at least one T allele (CT or TT genotypes) had a significantly increased CAD risk than the CC genotypes, with a ratio of 1.78 to 1 (OR = 1.780, 95%CI = 1.311-2.418). There was a close association between -184 T allele and 3VD (OR = 1.614, 95%CI = 1.259-2.07, P < 0.05). We conclude that the -184C>T of MKL1 is an important susceptibility factor for CAD in the Han Chinese in Henan Province. Homozygosity for the T allele is not only associated with an increased risk for CAD, it is also correlated with severity of stenosis in the Chinese Han population."xsd:string |
| http://purl.uniprot.org/citations/24615024 | http://purl.org/dc/terms/identifier | "doi:10.4238/2014.january.28.4"xsd:string |
| http://purl.uniprot.org/citations/24615024 | http://purl.uniprot.org/core/author | "Guo Y."xsd:string |
| http://purl.uniprot.org/citations/24615024 | http://purl.uniprot.org/core/author | "Li B."xsd:string |
| http://purl.uniprot.org/citations/24615024 | http://purl.uniprot.org/core/author | "Li D."xsd:string |
| http://purl.uniprot.org/citations/24615024 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
| http://purl.uniprot.org/citations/24615024 | http://purl.uniprot.org/core/author | "Zhang X.Y."xsd:string |
| http://purl.uniprot.org/citations/24615024 | http://purl.uniprot.org/core/author | "Zhu Z.Y."xsd:string |
| http://purl.uniprot.org/citations/24615024 | http://purl.uniprot.org/core/author | "Chen S.H."xsd:string |
| http://purl.uniprot.org/citations/24615024 | http://purl.uniprot.org/core/author | "Cui C.H."xsd:string |
| http://purl.uniprot.org/citations/24615024 | http://purl.uniprot.org/core/author | "Zhao X.F."xsd:string |
| http://purl.uniprot.org/citations/24615024 | http://purl.uniprot.org/core/author | "Bao Y.Z."xsd:string |
| http://purl.uniprot.org/citations/24615024 | http://purl.uniprot.org/core/author | "Shi Y.N."xsd:string |
| http://purl.uniprot.org/citations/24615024 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24615024 | http://purl.uniprot.org/core/name | "Genet Mol Res"xsd:string |
| http://purl.uniprot.org/citations/24615024 | http://purl.uniprot.org/core/pages | "590-597"xsd:string |
| http://purl.uniprot.org/citations/24615024 | http://purl.uniprot.org/core/title | "MKL1-184C>T gene polymorphism is associated with coronary artery disease in the Chinese Han population."xsd:string |
| http://purl.uniprot.org/citations/24615024 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/24615024 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24615024 |
| http://purl.uniprot.org/citations/24615024 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24615024 |
| http://purl.uniprot.org/uniprot/#_B0QY84-mappedCitation-24615024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24615024 |
| http://purl.uniprot.org/uniprot/#_A4FUJ8-mappedCitation-24615024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24615024 |
| http://purl.uniprot.org/uniprot/#_L8E8L9-mappedCitation-24615024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24615024 |
| http://purl.uniprot.org/uniprot/#_Q29R68-mappedCitation-24615024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24615024 |