| http://purl.uniprot.org/citations/24616493 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24616493 | http://www.w3.org/2000/01/rdf-schema#comment | "To gain insights into coordinated lineage-specification and morphogenetic processes during early embryogenesis, here we report a systematic identification of transcriptional programs mediated by a key developmental regulator--Brachyury. High-resolution chromosomal localization mapping of Brachyury by ChIP sequencing and ChIP-exonuclease revealed distinct sequence signatures enriched in Brachyury-bound enhancers. A combination of genome-wide in vitro and in vivo perturbation analysis and cross-species evolutionary comparison unveiled a detailed Brachyury-dependent gene-regulatory network that directly links the function of Brachyury to diverse developmental pathways and cellular housekeeping programs. We also show that Brachyury functions primarily as a transcriptional activator genome-wide and that an unexpected gene-regulatory feedback loop consisting of Brachyury, Foxa2, and Sox17 directs proper stem-cell lineage commitment during streak formation. Target gene and mRNA-sequencing correlation analysis of the T(c) mouse model supports a crucial role of Brachyury in up-regulating multiple key hematopoietic and muscle-fate regulators. Our results thus chart a comprehensive map of the Brachyury-mediated gene-regulatory network and how it influences in vivo developmental homeostasis and coordination."xsd:string |
| http://purl.uniprot.org/citations/24616493 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1402612111"xsd:string |
| http://purl.uniprot.org/citations/24616493 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/24616493 | http://purl.uniprot.org/core/author | "Tjian R."xsd:string |
| http://purl.uniprot.org/citations/24616493 | http://purl.uniprot.org/core/author | "Valenzuela P.D."xsd:string |
| http://purl.uniprot.org/citations/24616493 | http://purl.uniprot.org/core/author | "Lolas M."xsd:string |
| http://purl.uniprot.org/citations/24616493 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24616493 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/24616493 | http://purl.uniprot.org/core/pages | "4478-4483"xsd:string |
| http://purl.uniprot.org/citations/24616493 | http://purl.uniprot.org/core/title | "Charting Brachyury-mediated developmental pathways during early mouse embryogenesis."xsd:string |
| http://purl.uniprot.org/citations/24616493 | http://purl.uniprot.org/core/volume | "111"xsd:string |
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