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http://purl.uniprot.org/citations/24617547http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/24617547http://www.w3.org/2000/01/rdf-schema#comment"

Background

Fibrosis suppressors/activators in chronic heart failure (CHF) is a topic of investigation.

Aim

To quantify serum levels of fibrosis regulators in CHF.

Methods

ELISA tests were used to quantify fibrosis regulators, procollagen type-(PIP)I, (PIP)III, collagen-I, III, BMP1,2,3,7, SDF1α, CXCR4, fibulin 1,2,3, BMPER, CRIM1 and BAMBI in 66 CHF (NYHA class I, n = 9; II, n = 34; III n = 23), and in 14 controls.

Results

In CHF, TGFβR2, PIPIII, SDF1α and CRIM1 were increased. PIPIII correlated with CRIM1.

Conclusions

The BMPs inhibitor CRIM1 is increased and correlates with higher levels of serum PIPIII showing an imbalance in favor of pro-fibrotic mechanisms in CHF."xsd:string
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http://purl.uniprot.org/citations/24617547http://purl.uniprot.org/core/author"Cappello F."xsd:string
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http://purl.uniprot.org/citations/24617547http://purl.uniprot.org/core/author"Gnemmi I."xsd:string
http://purl.uniprot.org/citations/24617547http://purl.uniprot.org/core/author"Eleuteri E."xsd:string
http://purl.uniprot.org/citations/24617547http://purl.uniprot.org/core/author"Tarro Genta F."xsd:string
http://purl.uniprot.org/citations/24617547http://purl.uniprot.org/core/author"Ricciardolo F.L."xsd:string
http://purl.uniprot.org/citations/24617547http://purl.uniprot.org/core/author"Vallese D."xsd:string
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http://purl.uniprot.org/citations/24617547http://purl.uniprot.org/core/author"Pitruzzella A."xsd:string
http://purl.uniprot.org/citations/24617547http://purl.uniprot.org/core/date"2014"xsd:gYear
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http://purl.uniprot.org/citations/24617547http://purl.uniprot.org/core/pages"214-221"xsd:string
http://purl.uniprot.org/citations/24617547http://purl.uniprot.org/core/title"Fibrosis markers and CRIM1 increase in chronic heart failure of increasing severity."xsd:string
http://purl.uniprot.org/citations/24617547http://purl.uniprot.org/core/volume"19"xsd:string
http://purl.uniprot.org/citations/24617547http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/24617547
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