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http://purl.uniprot.org/citations/24619759http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Objectives

The aim of this study was to determine the prognostic relevance of colony-stimulating 1 receptor (CSF-1R) expression in both Hodgkin/Reed-Sternberg (HRS) cells and the surrounding cells (non-HRS cells) in patients with classical Hodgkin lymphoma (CHL) .

Methods

Diagnostic tissues from 112 patients with CHL treated with doxorubicin, bleomycin, vinblastine, and dacarbazine were evaluated retrospectively by immunohistochemical analysis for CSF-1R and CD68 and CD163 for tissue-associated macrophages.

Results

High numbers (≥30%) of non-HRS cells expressing CSF-1R conferred inferior event-free survival and overall survival in univariate and multivariate analysis. High numbers of non-HRS cells expressing CSF-1R were significantly associated with a high number of tumor-associated macrophages as detected by CD163 expression (P < .001). In particular, coexpression of CSF-1R and CD163 was associated with a worse survival outcome than either CSF-1R or CD163 expression alone or no expression.

Conclusions

Our data demonstrate that a high number of non-HRS cells expressing CSF-1R are correlated with an increased tumor macrophage content and worse survival."xsd:string
http://purl.uniprot.org/citations/24619759http://purl.org/dc/terms/identifier"doi:10.1309/ajcpr92tddfarisu"xsd:string
http://purl.uniprot.org/citations/24619759http://purl.uniprot.org/core/author"Park C."xsd:string
http://purl.uniprot.org/citations/24619759http://purl.uniprot.org/core/author"Yoon D.H."xsd:string
http://purl.uniprot.org/citations/24619759http://purl.uniprot.org/core/author"Huh J."xsd:string
http://purl.uniprot.org/citations/24619759http://purl.uniprot.org/core/author"Suh C."xsd:string
http://purl.uniprot.org/citations/24619759http://purl.uniprot.org/core/author"Koh Y.W."xsd:string
http://purl.uniprot.org/citations/24619759http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/24619759http://purl.uniprot.org/core/name"Am J Clin Pathol"xsd:string
http://purl.uniprot.org/citations/24619759http://purl.uniprot.org/core/pages"573-583"xsd:string
http://purl.uniprot.org/citations/24619759http://purl.uniprot.org/core/title"CSF-1R expression in tumor-associated macrophages is associated with worse prognosis in classical Hodgkin lymphoma."xsd:string
http://purl.uniprot.org/citations/24619759http://purl.uniprot.org/core/volume"141"xsd:string
http://purl.uniprot.org/citations/24619759http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/24619759
http://purl.uniprot.org/citations/24619759http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/24619759
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