| http://purl.uniprot.org/citations/24623417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24623417 | http://www.w3.org/2000/01/rdf-schema#comment | "UnlabelledKaposi's sarcoma-associated herpesvirus (KSHV) has been shown to be recognized by two families of pattern recognition receptors (PRRs), Toll-like receptors (TLRs) and NOD-like receptors (NLRs). Here we show that MAVS and RIG-I (retinoic acid-inducible gene 1), an RLR family member, also have a role in suppressing KSHV replication and production. In the context of primary infection, we show that in cells with depleted levels of MAVS or RIG-I, KSHV transcription is increased, while beta interferon (IFN-β) induction is attenuated. We also observed that MAVS and RIG-I are critical during the process of reactivation. Depletion of MAVS and RIG-I prior to reactivation led to increased viral load and production of infectious virus. Finally, MAVS depletion in latent KSHV-infected B cells leads to increased viral gene transcription. Overall, this study suggests a role for MAVS and RIG-I signaling during different stages of the KSHV life cycle.ImportanceWe show that RIG-I and its adaptor protein, MAVS, can sense KSHV infection and that these proteins can suppress KSHV replication following primary infection and/or viral reactivation."xsd:string |
| http://purl.uniprot.org/citations/24623417 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.03226-13"xsd:string |
| http://purl.uniprot.org/citations/24623417 | http://purl.uniprot.org/core/author | "Dittmer D.P."xsd:string |
| http://purl.uniprot.org/citations/24623417 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/24623417 | http://purl.uniprot.org/core/author | "Damania B."xsd:string |
| http://purl.uniprot.org/citations/24623417 | http://purl.uniprot.org/core/author | "Jacobs S.R."xsd:string |
| http://purl.uniprot.org/citations/24623417 | http://purl.uniprot.org/core/author | "West J.A."xsd:string |
| http://purl.uniprot.org/citations/24623417 | http://purl.uniprot.org/core/author | "Gregory S.M."xsd:string |
| http://purl.uniprot.org/citations/24623417 | http://purl.uniprot.org/core/author | "Chugh P."xsd:string |
| http://purl.uniprot.org/citations/24623417 | http://purl.uniprot.org/core/author | "Host K.M."xsd:string |
| http://purl.uniprot.org/citations/24623417 | http://purl.uniprot.org/core/author | "Wicks M."xsd:string |
| http://purl.uniprot.org/citations/24623417 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24623417 | http://purl.uniprot.org/core/name | "J Virol"xsd:string |
| http://purl.uniprot.org/citations/24623417 | http://purl.uniprot.org/core/pages | "5778-5787"xsd:string |
| http://purl.uniprot.org/citations/24623417 | http://purl.uniprot.org/core/title | "An important role for mitochondrial antiviral signaling protein in the Kaposi's sarcoma-associated herpesvirus life cycle."xsd:string |
| http://purl.uniprot.org/citations/24623417 | http://purl.uniprot.org/core/volume | "88"xsd:string |
| http://purl.uniprot.org/citations/24623417 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24623417 |
| http://purl.uniprot.org/citations/24623417 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24623417 |
| http://purl.uniprot.org/uniprot/#_B3KN51-mappedCitation-24623417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24623417 |
| http://purl.uniprot.org/uniprot/#_B4DWT9-mappedCitation-24623417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24623417 |
| http://purl.uniprot.org/uniprot/#_B3KWW1-mappedCitation-24623417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24623417 |
| http://purl.uniprot.org/uniprot/#_Q3B797-mappedCitation-24623417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24623417 |
| http://purl.uniprot.org/uniprot/#_L8E813-mappedCitation-24623417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24623417 |
| http://purl.uniprot.org/uniprot/#_O95786-mappedCitation-24623417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24623417 |