| http://purl.uniprot.org/citations/24623772 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24623772 | http://www.w3.org/2000/01/rdf-schema#comment | "Aging is accompanied with behavioral and cognitive decline. Changes in the neurotransmitter level are associated with the age-related behavioral deterioration, but whether well-known longevity manipulations affect the function of neurotransmitter system in aging animals is largely unclear. Here we report that serotonin (5-HT) and dopamine (DA) level decrease with age in C. elegans. The reduction results in downregulation of the activity of neurons controlled by 5-HT/DA signaling, and deterioration of some important behaviors, including pharyngeal pumping, food-induced slowing responses, and male mating. Longevity manipulations differentially affect the age-related decline in neuronal level of 5-HT/DA. The reduction and resultant behavioral deterioration occur in long-lived worms with defective insulin signaling [daf-2(e1370), age-1(hx546)] or mitochondria function [isp-1(qm150), tpk-1(qm162)], but not in long-lived worms with dietary restriction eat-2(ad1116). A reduced expression level of dopa decarboxylase BAS-1, the shared enzyme for 5-HT/DA synthesis, is responsible for the decline in 5-HT/DA levels. RNAi assay revealed that the sustained 5-HT/DA level in neurons of aged eat-2(ad1116) worms requires PHA-4 and its effectors superoxide dismutases and catalases, suggesting the involvement of reactive oxygen species in the 5-HT/DA decline. Furthermore, we found that elevating 5-HT/DA ameliorates age-related deterioration of pharyngeal pumping, food-induced slowing responses, and male mating in both wild-type and daf-2(e1370) worms. Together, dietary restriction preserves healthy behaviors in aged worms at least partially by sustaining a high 5-HT/DA level, and elevating the 5-HT/DA level in wild-type and daf-2(e1370) worms improves their behaviors during aging."xsd:string |
| http://purl.uniprot.org/citations/24623772 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.4013-13.2014"xsd:string |
| http://purl.uniprot.org/citations/24623772 | http://purl.uniprot.org/core/author | "Jiang J."xsd:string |
| http://purl.uniprot.org/citations/24623772 | http://purl.uniprot.org/core/author | "Yuan J."xsd:string |
| http://purl.uniprot.org/citations/24623772 | http://purl.uniprot.org/core/author | "Liu X.J."xsd:string |
| http://purl.uniprot.org/citations/24623772 | http://purl.uniprot.org/core/author | "Cai S.Q."xsd:string |
| http://purl.uniprot.org/citations/24623772 | http://purl.uniprot.org/core/author | "Yin J.A."xsd:string |
| http://purl.uniprot.org/citations/24623772 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24623772 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/24623772 | http://purl.uniprot.org/core/pages | "3947-3958"xsd:string |
| http://purl.uniprot.org/citations/24623772 | http://purl.uniprot.org/core/title | "Longevity manipulations differentially affect serotonin/dopamine level and behavioral deterioration in aging Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/24623772 | http://purl.uniprot.org/core/volume | "34"xsd:string |
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