| http://purl.uniprot.org/citations/24623780 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24623780 | http://www.w3.org/2000/01/rdf-schema#comment | "The growth of axons is an intricately regulated process involving intracellular signaling cascades and gene transcription. We had previously shown that the stimulus-dependent transcription factor, serum response factor (SRF), plays a critical role in regulating axon growth in the mammalian brain. However, the molecular mechanisms underlying SRF-dependent axon growth remains unknown. Here we report that SRF is phosphorylated and activated by GSK-3 to promote axon outgrowth in mouse hippocampal neurons. GSK-3 binds to and directly phosphorylates SRF on a highly conserved serine residue. This serine phosphorylation is necessary for SRF activity and for its interaction with MKL-family cofactors, MKL1 and MKL2, but not with TCF-family cofactor, ELK-1. Axonal growth deficits caused by GSK-3 inhibition could be rescued by expression of a constitutively active SRF. The SRF target gene and actin-binding protein, vinculin, is sufficient to overcome the axonal growth deficits of SRF-deficient and GSK-3-inhibited neurons. Furthermore, short hairpin RNA-mediated knockdown of vinculin also attenuated axonal growth. Thus, our findings reveal a novel phosphorylation and activation of SRF by GSK-3 that is critical for SRF-dependent axon growth in mammalian central neurons."xsd:string |
| http://purl.uniprot.org/citations/24623780 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.4677-12.2014"xsd:string |
| http://purl.uniprot.org/citations/24623780 | http://purl.uniprot.org/core/author | "Li C.L."xsd:string |
| http://purl.uniprot.org/citations/24623780 | http://purl.uniprot.org/core/author | "Ramanan N."xsd:string |
| http://purl.uniprot.org/citations/24623780 | http://purl.uniprot.org/core/author | "Oldenborg A."xsd:string |
| http://purl.uniprot.org/citations/24623780 | http://purl.uniprot.org/core/author | "Sathyamurthy A."xsd:string |
| http://purl.uniprot.org/citations/24623780 | http://purl.uniprot.org/core/author | "Tank D."xsd:string |
| http://purl.uniprot.org/citations/24623780 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24623780 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/24623780 | http://purl.uniprot.org/core/pages | "4027-4042"xsd:string |
| http://purl.uniprot.org/citations/24623780 | http://purl.uniprot.org/core/title | "SRF phosphorylation by glycogen synthase kinase-3 promotes axon growth in hippocampal neurons."xsd:string |
| http://purl.uniprot.org/citations/24623780 | http://purl.uniprot.org/core/volume | "34"xsd:string |
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| http://purl.uniprot.org/uniprot/Q64727#attribution-13420DBBFC84CAEAF623F6D74EC1A418 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24623780 |
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