| http://purl.uniprot.org/citations/24626927 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24626927 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24626927 | http://www.w3.org/2000/01/rdf-schema#comment | "Histone variants have been proposed to act as determinants for posttranslational modifications with widespread regulatory functions. We identify a histone-modifying enzyme that selectively methylates the replication-dependent histone H3 variant H3.1. The crystal structure of the SET domain of the histone H3 lysine-27 (H3K27) methyltransferase ARABIDOPSIS TRITHORAX-RELATED PROTEIN 5 (ATXR5) in complex with a H3.1 peptide shows that ATXR5 contains a bipartite catalytic domain that specifically "reads" alanine-31 of H3.1. Variation at position 31 between H3.1 and replication-independent H3.3 is conserved in plants and animals, and threonine-31 in H3.3 is responsible for inhibiting the activity of ATXR5 and its paralog, ATXR6. Our results suggest a simple model for the mitotic inheritance of the heterochromatic mark H3K27me1 and the protection of H3.3-enriched genes against heterochromatization during DNA replication."xsd:string |
| http://purl.uniprot.org/citations/24626927 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1248357"xsd:string |
| http://purl.uniprot.org/citations/24626927 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1248357"xsd:string |
| http://purl.uniprot.org/citations/24626927 | http://purl.uniprot.org/core/author | "Donoghue M.T."xsd:string |
| http://purl.uniprot.org/citations/24626927 | http://purl.uniprot.org/core/author | "Donoghue M.T."xsd:string |
| http://purl.uniprot.org/citations/24626927 | http://purl.uniprot.org/core/author | "Martienssen R.A."xsd:string |
| http://purl.uniprot.org/citations/24626927 | http://purl.uniprot.org/core/author | "Martienssen R.A."xsd:string |
| http://purl.uniprot.org/citations/24626927 | http://purl.uniprot.org/core/author | "Brunzelle J.S."xsd:string |
| http://purl.uniprot.org/citations/24626927 | http://purl.uniprot.org/core/author | "Brunzelle J.S."xsd:string |
| http://purl.uniprot.org/citations/24626927 | http://purl.uniprot.org/core/author | "Michaels S.D."xsd:string |
| http://purl.uniprot.org/citations/24626927 | http://purl.uniprot.org/core/author | "Michaels S.D."xsd:string |
| http://purl.uniprot.org/citations/24626927 | http://purl.uniprot.org/core/author | "Reinberg D."xsd:string |
| http://purl.uniprot.org/citations/24626927 | http://purl.uniprot.org/core/author | "Reinberg D."xsd:string |
| http://purl.uniprot.org/citations/24626927 | http://purl.uniprot.org/core/author | "Jacob Y."xsd:string |
| http://purl.uniprot.org/citations/24626927 | http://purl.uniprot.org/core/author | "Jacob Y."xsd:string |
| http://purl.uniprot.org/citations/24626927 | http://purl.uniprot.org/core/author | "Bergamin E."xsd:string |
| http://purl.uniprot.org/citations/24626927 | http://purl.uniprot.org/core/author | "Bergamin E."xsd:string |
| http://purl.uniprot.org/citations/24626927 | http://purl.uniprot.org/core/author | "Couture J.F."xsd:string |
| http://purl.uniprot.org/citations/24626927 | http://purl.uniprot.org/core/author | "Couture J.F."xsd:string |
| http://purl.uniprot.org/citations/24626927 | http://purl.uniprot.org/core/author | "LeBlanc C."xsd:string |
| http://purl.uniprot.org/citations/24626927 | http://purl.uniprot.org/core/author | "LeBlanc C."xsd:string |
| http://purl.uniprot.org/citations/24626927 | http://purl.uniprot.org/core/author | "Mongeon V."xsd:string |
| http://purl.uniprot.org/citations/24626927 | http://purl.uniprot.org/core/author | "Mongeon V."xsd:string |