| http://purl.uniprot.org/citations/24627487 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24627487 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24627487 | http://www.w3.org/2000/01/rdf-schema#comment | "Transforming growth factor (TGF)-β signaling is deliberately regulated at multiple steps in its pathway from the extracellular microenvironment to the nucleus. However, how TGF-β signaling is activated or attenuated is not fully understood. We recently identified transmembrane prostate androgen-induced RNA (TMEPAI), which is involved in a negative feedback loop of TGF-β signaling. When we searched for a family molecule(s) for TMEPAI, we found C18ORF1, which, like TMEPAI, possesses two PY motifs and one Smad-interacting motif (SIM) domain. As expected, C18ORF1 could block TGF-β signaling but not bone morphogenetic protein signaling. C18ORF1 bound to Smad2/3 via its SIM and competed with the Smad anchor for receptor activation for Smad2/3 binding to attenuate recruitment of Smad2/3 to the TGF-β type I receptor (also termed activin receptor-like kinase 5 (ALK5)), in a similar fashion to TMEPAI. Knockdown of C18ORF1 prolonged duration of TGF-β-induced Smad2 phosphorylation and concomitantly potentiated the expression of JunB, p21, and TMEPAI mRNAs induced by TGF-β. Consistently, TGF-β-induced cell migration was enhanced by the knockdown of C18ORF1. These results indicate that the inhibitory function of C18ORF1 on TGF-β signaling is similar to that of TMEPAI. However, in contrast to TMEPAI, C18ORF1 was not induced upon TGF-β signaling. Thus, we defined C18ORF1 as a surveillant of steady state TGF-β signaling, whereas TMEPAI might help C18ORF1 to inhibit TGF-β signaling in a coordinated manner when cells are stimulated with high levels of TGF-β."xsd:string |
| http://purl.uniprot.org/citations/24627487 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m114.558981"xsd:string |
| http://purl.uniprot.org/citations/24627487 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m114.558981"xsd:string |
| http://purl.uniprot.org/citations/24627487 | http://purl.uniprot.org/core/author | "Kato M."xsd:string |
| http://purl.uniprot.org/citations/24627487 | http://purl.uniprot.org/core/author | "Kato M."xsd:string |
| http://purl.uniprot.org/citations/24627487 | http://purl.uniprot.org/core/author | "Nakano N."xsd:string |
| http://purl.uniprot.org/citations/24627487 | http://purl.uniprot.org/core/author | "Nakano N."xsd:string |
| http://purl.uniprot.org/citations/24627487 | http://purl.uniprot.org/core/author | "Nakata M."xsd:string |
| http://purl.uniprot.org/citations/24627487 | http://purl.uniprot.org/core/author | "Nakata M."xsd:string |
| http://purl.uniprot.org/citations/24627487 | http://purl.uniprot.org/core/author | "Watanabe Y."xsd:string |
| http://purl.uniprot.org/citations/24627487 | http://purl.uniprot.org/core/author | "Watanabe Y."xsd:string |
| http://purl.uniprot.org/citations/24627487 | http://purl.uniprot.org/core/author | "Itoh S."xsd:string |
| http://purl.uniprot.org/citations/24627487 | http://purl.uniprot.org/core/author | "Itoh S."xsd:string |
| http://purl.uniprot.org/citations/24627487 | http://purl.uniprot.org/core/author | "Sakata N."xsd:string |
| http://purl.uniprot.org/citations/24627487 | http://purl.uniprot.org/core/author | "Sakata N."xsd:string |
| http://purl.uniprot.org/citations/24627487 | http://purl.uniprot.org/core/author | "Ikeno S."xsd:string |
| http://purl.uniprot.org/citations/24627487 | http://purl.uniprot.org/core/author | "Ikeno S."xsd:string |
| http://purl.uniprot.org/citations/24627487 | http://purl.uniprot.org/core/author | "Itoh F."xsd:string |
| http://purl.uniprot.org/citations/24627487 | http://purl.uniprot.org/core/author | "Itoh F."xsd:string |
| http://purl.uniprot.org/citations/24627487 | http://purl.uniprot.org/core/author | "Katsu Y."xsd:string |
| http://purl.uniprot.org/citations/24627487 | http://purl.uniprot.org/core/author | "Katsu Y."xsd:string |
| http://purl.uniprot.org/citations/24627487 | http://purl.uniprot.org/core/author | "Togawa Y."xsd:string |
| http://purl.uniprot.org/citations/24627487 | http://purl.uniprot.org/core/author | "Togawa Y."xsd:string |