| http://purl.uniprot.org/citations/2463100 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2463100 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2463100 | http://www.w3.org/2000/01/rdf-schema#comment | "Cluster of differentiation ([CD]) 19 antigens are B-cell-specific molecules expressed on virtually all human cells of the B-lymphocyte lineage except plasma cells. We produced a new anti-CD19 monoclonal antibody (McAb), CLB-CD19, that was used to study the role of CD19 molecules in B-cell activation. Anti-CD19 McAb induced mobilization of free intracellular calcium ([Ca2+]i) in Daudi cells, but not in normal spleen or tonsillar B cells, for which crosslinking with a second anti-mouse Ig antibody was not required. Anti-CD19 McAb inhibited B-cell proliferation induced by anti-IgM coupled to Sepharose beads. This inhibitory effect was overcome by the addition of nonmitogenic concentrations of phorbol myristate acetate. Anti-CD19 McAb did not interfere with Staphylococcus aureus- or B-cell growth factor-induced B-cell proliferation. Anti-CD19 McAb inhibited T-cell-dependent polyclonal B-cell differentiation in pokeweed mitogen-, interleukin 2-, or anti-CD3-driven culture systems. Delayed addition studies showed that once differentiation of B cells was induced, CD19 molecules lost their regulating function. Taken together, our results indicate that CD19 molecules play a regulatory role in B-cell proliferation and differentiation."xsd:string |
| http://purl.uniprot.org/citations/2463100 | http://purl.org/dc/terms/identifier | "doi:10.1016/0008-8749(89)90385-7"xsd:string |
| http://purl.uniprot.org/citations/2463100 | http://purl.org/dc/terms/identifier | "doi:10.1016/0008-8749(89)90385-7"xsd:string |
| http://purl.uniprot.org/citations/2463100 | http://purl.uniprot.org/core/author | "Schumacher T.N."xsd:string |
| http://purl.uniprot.org/citations/2463100 | http://purl.uniprot.org/core/author | "Schumacher T.N."xsd:string |
| http://purl.uniprot.org/citations/2463100 | http://purl.uniprot.org/core/author | "van Lier R.A."xsd:string |
| http://purl.uniprot.org/citations/2463100 | http://purl.uniprot.org/core/author | "van Lier R.A."xsd:string |
| http://purl.uniprot.org/citations/2463100 | http://purl.uniprot.org/core/author | "Miedema F."xsd:string |
| http://purl.uniprot.org/citations/2463100 | http://purl.uniprot.org/core/author | "Miedema F."xsd:string |
| http://purl.uniprot.org/citations/2463100 | http://purl.uniprot.org/core/author | "de Rie M.A."xsd:string |
| http://purl.uniprot.org/citations/2463100 | http://purl.uniprot.org/core/author | "de Rie M.A."xsd:string |
| http://purl.uniprot.org/citations/2463100 | http://purl.uniprot.org/core/author | "van Schijndel G.M."xsd:string |
| http://purl.uniprot.org/citations/2463100 | http://purl.uniprot.org/core/author | "van Schijndel G.M."xsd:string |
| http://purl.uniprot.org/citations/2463100 | http://purl.uniprot.org/core/date | "1989"xsd:gYear |
| http://purl.uniprot.org/citations/2463100 | http://purl.uniprot.org/core/date | "1989"xsd:gYear |
| http://purl.uniprot.org/citations/2463100 | http://purl.uniprot.org/core/name | "Cell. Immunol."xsd:string |
| http://purl.uniprot.org/citations/2463100 | http://purl.uniprot.org/core/name | "Cell. Immunol."xsd:string |
| http://purl.uniprot.org/citations/2463100 | http://purl.uniprot.org/core/pages | "368-381"xsd:string |
| http://purl.uniprot.org/citations/2463100 | http://purl.uniprot.org/core/pages | "368-381"xsd:string |
| http://purl.uniprot.org/citations/2463100 | http://purl.uniprot.org/core/title | "Regulatory role of CD19 molecules in B-cell activation and differentiation."xsd:string |
| http://purl.uniprot.org/citations/2463100 | http://purl.uniprot.org/core/title | "Regulatory role of CD19 molecules in B-cell activation and differentiation."xsd:string |
| http://purl.uniprot.org/citations/2463100 | http://purl.uniprot.org/core/volume | "118"xsd:string |
| http://purl.uniprot.org/citations/2463100 | http://purl.uniprot.org/core/volume | "118"xsd:string |