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http://purl.uniprot.org/citations/24631219http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/24631219http://www.w3.org/2000/01/rdf-schema#comment"We conducted a case-control study to investigate the possible association between the head and neck cancer (HNC) and genetic variability of Rad51C tumor suppressor gene. Eight polymorphic sites spanning over non-coding regions of Rad51C promoter, exon 1 and intron 1 were genotyped in 81 HNC cases and 156 healthy controls using the real-time PCR technique. One investigated site turned out to be not polymorphic, while among the remaining seven sites a significant HNC risk-increasing effect was found for rs16943176 (c.-118G>A), rs12946397 (c.-26C>T) and rs17222691 (c.145+947C>T) on both allelic (OR=1.8; p<0.05) and genotypic (OR=2.0; p<0.05) level. Furthermore, our data seem to provide marginal evidence, that this effect might possibly be confined to women only (OR=2.8; p=0.05 for allelic and OR=3.7; p=0.05 for genotypic comparisons). These SNPs were found to co-segregate together forming two distinct, HNC risk-modulating haplotypes. The genetic variability of Rad51C might thus be of relevance with respect to HNC risk."xsd:string
http://purl.uniprot.org/citations/24631219http://purl.org/dc/terms/identifier"doi:10.1016/j.mrfmmm.2014.02.007"xsd:string
http://purl.uniprot.org/citations/24631219http://purl.uniprot.org/core/author"Rydzynski K."xsd:string
http://purl.uniprot.org/citations/24631219http://purl.uniprot.org/core/author"Wasowicz W."xsd:string
http://purl.uniprot.org/citations/24631219http://purl.uniprot.org/core/author"Gromadzinska J."xsd:string
http://purl.uniprot.org/citations/24631219http://purl.uniprot.org/core/author"Gresner P."xsd:string
http://purl.uniprot.org/citations/24631219http://purl.uniprot.org/core/author"Twardowska E."xsd:string
http://purl.uniprot.org/citations/24631219http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/24631219http://purl.uniprot.org/core/name"Mutat Res"xsd:string
http://purl.uniprot.org/citations/24631219http://purl.uniprot.org/core/pages"47-54"xsd:string
http://purl.uniprot.org/citations/24631219http://purl.uniprot.org/core/title"Rad51C: a novel suppressor gene modulates the risk of head and neck cancer."xsd:string
http://purl.uniprot.org/citations/24631219http://purl.uniprot.org/core/volume"762"xsd:string
http://purl.uniprot.org/citations/24631219http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/24631219
http://purl.uniprot.org/citations/24631219http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/24631219
http://purl.uniprot.org/uniprot/#_A0A8V8TMU8-mappedCitation-24631219http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24631219
http://purl.uniprot.org/uniprot/#_B4E0G0-mappedCitation-24631219http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24631219
http://purl.uniprot.org/uniprot/#_O43502-mappedCitation-24631219http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24631219
http://purl.uniprot.org/uniprot/#_Q7KZJ0-mappedCitation-24631219http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/24631219
http://purl.uniprot.org/uniprot/O43502http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/24631219
http://purl.uniprot.org/uniprot/B4E0G0http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/24631219
http://purl.uniprot.org/uniprot/A0A8V8TMU8http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/24631219
http://purl.uniprot.org/uniprot/Q7KZJ0http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/24631219