http://purl.uniprot.org/citations/24631219 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/24631219 | http://www.w3.org/2000/01/rdf-schema#comment | "We conducted a case-control study to investigate the possible association between the head and neck cancer (HNC) and genetic variability of Rad51C tumor suppressor gene. Eight polymorphic sites spanning over non-coding regions of Rad51C promoter, exon 1 and intron 1 were genotyped in 81 HNC cases and 156 healthy controls using the real-time PCR technique. One investigated site turned out to be not polymorphic, while among the remaining seven sites a significant HNC risk-increasing effect was found for rs16943176 (c.-118G>A), rs12946397 (c.-26C>T) and rs17222691 (c.145+947C>T) on both allelic (OR=1.8; p<0.05) and genotypic (OR=2.0; p<0.05) level. Furthermore, our data seem to provide marginal evidence, that this effect might possibly be confined to women only (OR=2.8; p=0.05 for allelic and OR=3.7; p=0.05 for genotypic comparisons). These SNPs were found to co-segregate together forming two distinct, HNC risk-modulating haplotypes. The genetic variability of Rad51C might thus be of relevance with respect to HNC risk."xsd:string |
http://purl.uniprot.org/citations/24631219 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mrfmmm.2014.02.007"xsd:string |
http://purl.uniprot.org/citations/24631219 | http://purl.uniprot.org/core/author | "Rydzynski K."xsd:string |
http://purl.uniprot.org/citations/24631219 | http://purl.uniprot.org/core/author | "Wasowicz W."xsd:string |
http://purl.uniprot.org/citations/24631219 | http://purl.uniprot.org/core/author | "Gromadzinska J."xsd:string |
http://purl.uniprot.org/citations/24631219 | http://purl.uniprot.org/core/author | "Gresner P."xsd:string |
http://purl.uniprot.org/citations/24631219 | http://purl.uniprot.org/core/author | "Twardowska E."xsd:string |
http://purl.uniprot.org/citations/24631219 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
http://purl.uniprot.org/citations/24631219 | http://purl.uniprot.org/core/name | "Mutat Res"xsd:string |
http://purl.uniprot.org/citations/24631219 | http://purl.uniprot.org/core/pages | "47-54"xsd:string |
http://purl.uniprot.org/citations/24631219 | http://purl.uniprot.org/core/title | "Rad51C: a novel suppressor gene modulates the risk of head and neck cancer."xsd:string |
http://purl.uniprot.org/citations/24631219 | http://purl.uniprot.org/core/volume | "762"xsd:string |
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