| http://purl.uniprot.org/citations/24632570 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24632570 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24632570 | http://www.w3.org/2000/01/rdf-schema#comment | "Thymic stromal lymphopoietin (TSLP), a cytokine produced by epithelial cells at barrier surfaces, is pivotal for the development of widespread chronic inflammatory disorders such as asthma and atopic dermatitis. The structure of the mouse TSLP-mediated signaling complex reveals how TSLP establishes extensive interfaces with its cognate receptor (TSLPR) and the shared interleukin 7 receptor α-chain (IL-7Rα) to evoke membrane-proximal receptor-receptor contacts poised for intracellular signaling. Binding of TSLP to TSLPR is a mechanistic prerequisite for recruitment of IL-7Rα to the high-affinity ternary complex, which we propose is coupled to a structural switch in TSLP at the crossroads of the cytokine-receptor interfaces. Functional interrogation of TSLP-receptor interfaces points to putative interaction hotspots that could be exploited for antagonist design. Finally, we derive the structural rationale for the functional duality of IL-7Rα and establish a consensus for the geometry of ternary complexes mediated by interleukin 2 (IL-2)-family cytokines."xsd:string |
| http://purl.uniprot.org/citations/24632570 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.2794"xsd:string |
| http://purl.uniprot.org/citations/24632570 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.2794"xsd:string |
| http://purl.uniprot.org/citations/24632570 | http://purl.uniprot.org/core/author | "Savvides S.N."xsd:string |
| http://purl.uniprot.org/citations/24632570 | http://purl.uniprot.org/core/author | "Savvides S.N."xsd:string |
| http://purl.uniprot.org/citations/24632570 | http://purl.uniprot.org/core/author | "Bloch Y."xsd:string |
| http://purl.uniprot.org/citations/24632570 | http://purl.uniprot.org/core/author | "Bloch Y."xsd:string |
| http://purl.uniprot.org/citations/24632570 | http://purl.uniprot.org/core/author | "Verstraete K."xsd:string |
| http://purl.uniprot.org/citations/24632570 | http://purl.uniprot.org/core/author | "Verstraete K."xsd:string |
| http://purl.uniprot.org/citations/24632570 | http://purl.uniprot.org/core/author | "Tavernier J."xsd:string |
| http://purl.uniprot.org/citations/24632570 | http://purl.uniprot.org/core/author | "Tavernier J."xsd:string |
| http://purl.uniprot.org/citations/24632570 | http://purl.uniprot.org/core/author | "Pauwels E."xsd:string |
| http://purl.uniprot.org/citations/24632570 | http://purl.uniprot.org/core/author | "Pauwels E."xsd:string |
| http://purl.uniprot.org/citations/24632570 | http://purl.uniprot.org/core/author | "Peelman F."xsd:string |
| http://purl.uniprot.org/citations/24632570 | http://purl.uniprot.org/core/author | "Peelman F."xsd:string |
| http://purl.uniprot.org/citations/24632570 | http://purl.uniprot.org/core/author | "Vyncke L."xsd:string |
| http://purl.uniprot.org/citations/24632570 | http://purl.uniprot.org/core/author | "Vyncke L."xsd:string |
| http://purl.uniprot.org/citations/24632570 | http://purl.uniprot.org/core/author | "van Schie L."xsd:string |
| http://purl.uniprot.org/citations/24632570 | http://purl.uniprot.org/core/author | "van Schie L."xsd:string |
| http://purl.uniprot.org/citations/24632570 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24632570 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24632570 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/24632570 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |