| http://purl.uniprot.org/citations/24632947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24632947 | http://www.w3.org/2000/01/rdf-schema#comment | "The rapid clearance of dying cells is important for the well-being of multicellular organisms. In C. elegans, cell corpse removal is mainly mediated by three parallel engulfment signaling cascades. These pathways include two small GTPases, MIG-2/RhoG and CED-10/Rac1. Here we present the identification and characterization of CDC-42 as a third GTPase involved in the regulation of cell corpse clearance. Genetic analyses performed by both loss of cdc-42 function and cdc-42 overexpression place cdc-42 in parallel to the ced-2/5/12 signaling module, in parallel to or upstream of the ced-10 module, and downstream of the ced-1/6/7 module. CDC-42 accumulates in engulfing cells at membranes surrounding apoptotic corpses. The formation of such halos depends on the integrins PAT-2/PAT-3, UNC-112 and the GEF protein UIG-1, but not on the canonical ced-1/6/7 or ced-2/5/12 signaling modules. Together, our results suggest that the small GTPase CDC-42 regulates apoptotic cell engulfment possibly upstream of the canonical Rac GTPase CED-10, by polarizing the engulfing cell toward the apoptotic corpse in response to integrin signaling and ced-1/6/7 signaling in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/24632947 | http://purl.org/dc/terms/identifier | "doi:10.1038/cdd.2014.23"xsd:string |
| http://purl.uniprot.org/citations/24632947 | http://purl.uniprot.org/core/author | "Hengartner M.O."xsd:string |
| http://purl.uniprot.org/citations/24632947 | http://purl.uniprot.org/core/author | "Zeng S."xsd:string |
| http://purl.uniprot.org/citations/24632947 | http://purl.uniprot.org/core/author | "Neukomm L.J."xsd:string |
| http://purl.uniprot.org/citations/24632947 | http://purl.uniprot.org/core/author | "Frei A.P."xsd:string |
| http://purl.uniprot.org/citations/24632947 | http://purl.uniprot.org/core/author | "Huegli P.A."xsd:string |
| http://purl.uniprot.org/citations/24632947 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24632947 | http://purl.uniprot.org/core/name | "Cell Death Differ"xsd:string |
| http://purl.uniprot.org/citations/24632947 | http://purl.uniprot.org/core/pages | "845-853"xsd:string |
| http://purl.uniprot.org/citations/24632947 | http://purl.uniprot.org/core/title | "Small GTPase CDC-42 promotes apoptotic cell corpse clearance in response to PAT-2 and CED-1 in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/24632947 | http://purl.uniprot.org/core/volume | "21"xsd:string |
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| http://purl.uniprot.org/citations/24632947 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24632947 |
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