| http://purl.uniprot.org/citations/24656046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24656046 | http://www.w3.org/2000/01/rdf-schema#comment | "Production of type I interferons (IFN-I) is a crucial innate immune mechanism against viral infections. IFN-I induction is subject to negative regulation by both viral and cellular factors, but the underlying mechanism remains unclear. We report that the noncanonical NF-κB pathway was stimulated along with innate immune cell differentiation and viral infections and had a vital role in negatively regulating IFN-I induction. Genetic deficiencies in major components of the noncanonical NF-κB pathway caused IFN-I hyperinduction and rendered cells and mice substantially more resistant to viral infection. Noncanonical NF-κB suppressed signal-induced histone modifications at the Ifnb promoter, an action that involved attenuated recruitment of the transcription factor RelA and a histone demethylase, JMJD2A. These findings reveal an unexpected function of the noncanonical NF-κB pathway and highlight an important mechanism regulating antiviral innate immunity."xsd:string |
| http://purl.uniprot.org/citations/24656046 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2014.02.006"xsd:string |
| http://purl.uniprot.org/citations/24656046 | http://purl.uniprot.org/core/author | "Cheng X."xsd:string |
| http://purl.uniprot.org/citations/24656046 | http://purl.uniprot.org/core/author | "Hu H."xsd:string |
| http://purl.uniprot.org/citations/24656046 | http://purl.uniprot.org/core/author | "Jin J."xsd:string |
| http://purl.uniprot.org/citations/24656046 | http://purl.uniprot.org/core/author | "Xiao Y."xsd:string |
| http://purl.uniprot.org/citations/24656046 | http://purl.uniprot.org/core/author | "Yu J."xsd:string |
| http://purl.uniprot.org/citations/24656046 | http://purl.uniprot.org/core/author | "Zou Q."xsd:string |
| http://purl.uniprot.org/citations/24656046 | http://purl.uniprot.org/core/author | "Mallette F.A."xsd:string |
| http://purl.uniprot.org/citations/24656046 | http://purl.uniprot.org/core/author | "Li H.S."xsd:string |
| http://purl.uniprot.org/citations/24656046 | http://purl.uniprot.org/core/author | "Sun S.C."xsd:string |
| http://purl.uniprot.org/citations/24656046 | http://purl.uniprot.org/core/author | "Watowich S.S."xsd:string |
| http://purl.uniprot.org/citations/24656046 | http://purl.uniprot.org/core/author | "Brittain G.C."xsd:string |
| http://purl.uniprot.org/citations/24656046 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24656046 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/24656046 | http://purl.uniprot.org/core/pages | "342-354"xsd:string |
| http://purl.uniprot.org/citations/24656046 | http://purl.uniprot.org/core/title | "Noncanonical NF-kappaB pathway controls the production of type I interferons in antiviral innate immunity."xsd:string |
| http://purl.uniprot.org/citations/24656046 | http://purl.uniprot.org/core/volume | "40"xsd:string |
| http://purl.uniprot.org/citations/24656046 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24656046 |
| http://purl.uniprot.org/citations/24656046 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24656046 |
| http://purl.uniprot.org/uniprot/#_A0A077S2U6-mappedCitation-24656046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24656046 |
| http://purl.uniprot.org/uniprot/#_A0A140LI24-mappedCitation-24656046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24656046 |
| http://purl.uniprot.org/uniprot/#_A0A140LI46-mappedCitation-24656046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24656046 |
| http://purl.uniprot.org/uniprot/#_A0A140LJD6-mappedCitation-24656046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24656046 |