| http://purl.uniprot.org/citations/24657165 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24657165 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24657165 | http://www.w3.org/2000/01/rdf-schema#comment | "Timely DNA replication across damaged DNA is critical for maintaining genomic integrity. Translesion DNA synthesis (TLS) allows bypass of DNA lesions using error-prone TLS polymerases. The E3 ligase RAD18 is necessary for proliferating cell nuclear antigen (PCNA) monoubiquitination and TLS polymerase recruitment; however, the regulatory steps upstream of RAD18 activation are less understood. Here, we show that the UBZ4 domain-containing transcriptional repressor ZBTB1 is a critical upstream regulator of TLS. The UBZ4 motif is required for PCNA monoubiquitination and survival after UV damage. ZBTB1 associates with KAP-1, a transcriptional repressor whose phosphorylation relaxes chromatin after DNA damage. ZBTB1 depletion impairs formation of phospho-KAP-1 at UV damage sites and reduces RAD18 recruitment. Furthermore, phosphorylation of KAP-1 is necessary for efficient PCNA modification. We propose that ZBTB1 is required for localizing phospho-KAP-1 to chromatin and enhancing RAD18 accessibility. Collectively, our study implicates a ubiquitin-binding protein in orchestrating chromatin remodeling during DNA repair."xsd:string |
| http://purl.uniprot.org/citations/24657165 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2014.02.017"xsd:string |
| http://purl.uniprot.org/citations/24657165 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2014.02.017"xsd:string |
| http://purl.uniprot.org/citations/24657165 | http://purl.uniprot.org/core/author | "D'Andrea A.D."xsd:string |
| http://purl.uniprot.org/citations/24657165 | http://purl.uniprot.org/core/author | "D'Andrea A.D."xsd:string |
| http://purl.uniprot.org/citations/24657165 | http://purl.uniprot.org/core/author | "Kim H."xsd:string |
| http://purl.uniprot.org/citations/24657165 | http://purl.uniprot.org/core/author | "Kim H."xsd:string |
| http://purl.uniprot.org/citations/24657165 | http://purl.uniprot.org/core/author | "Yang K."xsd:string |
| http://purl.uniprot.org/citations/24657165 | http://purl.uniprot.org/core/author | "Yang K."xsd:string |
| http://purl.uniprot.org/citations/24657165 | http://purl.uniprot.org/core/author | "Adelmant G."xsd:string |
| http://purl.uniprot.org/citations/24657165 | http://purl.uniprot.org/core/author | "Adelmant G."xsd:string |
| http://purl.uniprot.org/citations/24657165 | http://purl.uniprot.org/core/author | "Marto J.A."xsd:string |
| http://purl.uniprot.org/citations/24657165 | http://purl.uniprot.org/core/author | "Marto J.A."xsd:string |
| http://purl.uniprot.org/citations/24657165 | http://purl.uniprot.org/core/author | "Ceccaldi R."xsd:string |
| http://purl.uniprot.org/citations/24657165 | http://purl.uniprot.org/core/author | "Ceccaldi R."xsd:string |
| http://purl.uniprot.org/citations/24657165 | http://purl.uniprot.org/core/author | "Dejsuphong D."xsd:string |
| http://purl.uniprot.org/citations/24657165 | http://purl.uniprot.org/core/author | "Dejsuphong D."xsd:string |
| http://purl.uniprot.org/citations/24657165 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24657165 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24657165 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/24657165 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/24657165 | http://purl.uniprot.org/core/pages | "107-118"xsd:string |
| http://purl.uniprot.org/citations/24657165 | http://purl.uniprot.org/core/pages | "107-118"xsd:string |