| http://purl.uniprot.org/citations/24657831 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24657831 | http://www.w3.org/2000/01/rdf-schema#comment | "Histone deacetylases (HDACs) constitute a super-family of enzymes grouped into four major classes (Class I-IV) that deacetylate histone tails leading to chromatin condensation and gene repression. Whether stroke-induced oligodendrogenesis is related to the expression of individual HDACs in the oligodendrocyte lineage has not been investigated. We found that 2 days after stroke, oligodendrocyte progenitor cells (OPCs) and mature oligodendrocytes (OLGs) were substantially reduced in the peri-infarct corpus callosum, whereas at 7 days after stroke, a robust increase in OPCs and OLGs was observed. Ischemic brains isolated from rats sacrificed 7 days after stroke were used to test levels of individual members of Class I (1 and 2) and Class II (4 and 5) HDACs in white matter oligodendrocytes during stroke-induced oligodendrogenesis. Double immunohistochemistry analysis revealed that stroke substantially increased the number of NG2+OPCs with nuclear HDAC1 and HDAC2 immunoreactivity and cytoplasmic HDAC4 which were associated with augmentation of proliferating OPCs, as determined by BrdU and Ki67 double reactive cells after stroke. A decrease in HDAC1 and an increase in HDAC2 immunoreactivity were detected in mature adenomatous polyposis coli (APC) positive OLGs, which paralleled an increase in newly generated BrdU positive OLGs in the peri-infarct corpus callosum. Concurrently, stroke substantially decreased the acetylation levels of histones H3 and H4 in both OPCs and OLGs. Taken together, these findings demonstrate that stroke induces distinct profiles of Class I and Class II HDACs in white matter OPCs and OLGs, suggesting that the individual members of Class I and II HDACs play divergent roles in the regulation of OPC proliferation and differentiation during brain repair after stroke."xsd:string |
| http://purl.uniprot.org/citations/24657831 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuint.2014.03.006"xsd:string |
| http://purl.uniprot.org/citations/24657831 | http://purl.uniprot.org/core/author | "Roberts C."xsd:string |
| http://purl.uniprot.org/citations/24657831 | http://purl.uniprot.org/core/author | "Zhang Z.G."xsd:string |
| http://purl.uniprot.org/citations/24657831 | http://purl.uniprot.org/core/author | "Liu X.S."xsd:string |
| http://purl.uniprot.org/citations/24657831 | http://purl.uniprot.org/core/author | "Chopp M."xsd:string |
| http://purl.uniprot.org/citations/24657831 | http://purl.uniprot.org/core/author | "Kassis H."xsd:string |
| http://purl.uniprot.org/citations/24657831 | http://purl.uniprot.org/core/author | "Shehadah A."xsd:string |
| http://purl.uniprot.org/citations/24657831 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24657831 | http://purl.uniprot.org/core/name | "Neurochem Int"xsd:string |
| http://purl.uniprot.org/citations/24657831 | http://purl.uniprot.org/core/pages | "17-23"xsd:string |
| http://purl.uniprot.org/citations/24657831 | http://purl.uniprot.org/core/title | "Histone deacetylase expression in white matter oligodendrocytes after stroke."xsd:string |
| http://purl.uniprot.org/citations/24657831 | http://purl.uniprot.org/core/volume | "77"xsd:string |
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