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http://purl.uniprot.org/citations/24658196http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Background

Few reports have studied the possible association between the haptoglobin (Hp) genotype and the risk of diabetic nephropathy (DN) in type 1 diabetes (T1D), with conflicting results to date.

Aims

To study whether the 2-2 Hp genotype is associated with an increased risk of overt DN in a Spanish population with T1D.

Methods

We performed a case-control study in a Spanish population.

Cases

T1D patients with end-stage renal disease (stage 5 of NKF-KDOQI), awaiting reno-pancreatic transplantation or having already been transplanted (reno-pancreatic or renal alone).

Controls

T1D patients, matched for sex and time of diabetes evolution, with preserved renal function and normal urinary albumin excretion. Hp genotyping was done using polymerase chain reaction and electrophoresis.

Results

We included 57 cases and 57 controls in the study. There were no statistically significant differences in gender (70% vs. 61% males, p=1.0) or the duration of diabetes (23.0 ± 6.7 vs. 20.8 ± 9.3 years; p=0.1), although the age of onset of diabetes was lower in the cases (14.1 ± 6.8 vs. 17.7 ± 10.1 years, p=0.03). The frequency of genotypes 1-1, 1-2 and 2-2 was 19.3%, 42.1% and 38.6% in cases and 17.5%, 49.1% and 33.4% in controls, respectively, with no statistically significant differences between groups (p=0.8). Conditional logistic regression analysis showed no significant association between genotype 2-2 of Hp and the development of DN (OR 1.14, CI 0.52-2.52).

Conclusions

In our sample of a Spanish population with T1D, no association was found between the Hp genotype and risk of overt DN."xsd:string
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http://purl.uniprot.org/citations/24658196http://purl.uniprot.org/core/author"Bosch-Comas A."xsd:string
http://purl.uniprot.org/citations/24658196http://purl.uniprot.org/core/author"Oriola J."xsd:string
http://purl.uniprot.org/citations/24658196http://purl.uniprot.org/core/author"Ricart M.J."xsd:string
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http://purl.uniprot.org/citations/24658196http://purl.uniprot.org/core/author"Amor A.J."xsd:string
http://purl.uniprot.org/citations/24658196http://purl.uniprot.org/core/author"Esmatjes E."xsd:string
http://purl.uniprot.org/citations/24658196http://purl.uniprot.org/core/author"de Hollanda A.M."xsd:string
http://purl.uniprot.org/citations/24658196http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/24658196http://purl.uniprot.org/core/name"Nefrologia"xsd:string
http://purl.uniprot.org/citations/24658196http://purl.uniprot.org/core/pages"212-215"xsd:string
http://purl.uniprot.org/citations/24658196http://purl.uniprot.org/core/title"Haptoglobin genotype and risk of diabetic nephropathy in patients with type 1 diabetes mellitus: a study on a Spanish population."xsd:string
http://purl.uniprot.org/citations/24658196http://purl.uniprot.org/core/volume"34"xsd:string
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