| http://purl.uniprot.org/citations/24658504 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24658504 | http://www.w3.org/2000/01/rdf-schema#comment | "Innate lymphoid cells (ILCs) are increasingly appreciated as important regulators of tissue homeostasis and inflammation. However, their role in human skin remains obscure. We found that healthy peripheral blood CD117(+) ILC3, lacking the natural cytotoxicity receptor (NCR) NKp44 (NCR(-) ILC3), CD117(-)NCR(-)CRTH2(-)CD161(+) ILC1, and CRTH2(+) ILC2, express the skin-homing receptor cutaneous lymphocyte antigen (CLA). NCR(+) ILC3 were scarce in peripheral blood. Consistently, we identified in normal skin ILC2 and NCR(-) ILC3, a small proportion of CD161(+) ILC1, and hardly any NCR(+) ILC3, whereas NCR(+) ILC3 were present in cultured dermal explants. The skin ILC2 and NCR(+) ILC3 subsets produced IL-13 and IL-22, respectively, upon cytokine stimulation. Remarkably, dermal NCR(-) ILC3 converted to NCR(+) ILC3 upon culture in IL-1β plus IL-23, cytokines known to be involved in psoriatic inflammation. In line with this observation, significantly increased proportions of NCR(+) ILC3 were present in lesional skin and peripheral blood of psoriasis patients as compared with skin and blood of healthy individuals, respectively, whereas the proportions of ILC2 and CD161(+) ILC1 remained unchanged. NCR(+) ILC3 from skin and blood of psoriasis patients produced IL-22, which is regarded as a key driver of epidermal thickening, suggesting that NCR(+) ILC3 may participate in psoriasis pathology."xsd:string |
| http://purl.uniprot.org/citations/24658504 | http://purl.org/dc/terms/identifier | "doi:10.1038/jid.2014.146"xsd:string |
| http://purl.uniprot.org/citations/24658504 | http://purl.uniprot.org/core/author | "Spits H."xsd:string |
| http://purl.uniprot.org/citations/24658504 | http://purl.uniprot.org/core/author | "Teunissen M.B.M."xsd:string |
| http://purl.uniprot.org/citations/24658504 | http://purl.uniprot.org/core/author | "Eidsmo L."xsd:string |
| http://purl.uniprot.org/citations/24658504 | http://purl.uniprot.org/core/author | "Hazenberg M.D."xsd:string |
| http://purl.uniprot.org/citations/24658504 | http://purl.uniprot.org/core/author | "Mjosberg J."xsd:string |
| http://purl.uniprot.org/citations/24658504 | http://purl.uniprot.org/core/author | "Bernink J.H."xsd:string |
| http://purl.uniprot.org/citations/24658504 | http://purl.uniprot.org/core/author | "Cheuk S."xsd:string |
| http://purl.uniprot.org/citations/24658504 | http://purl.uniprot.org/core/author | "Brouwer M.W.D."xsd:string |
| http://purl.uniprot.org/citations/24658504 | http://purl.uniprot.org/core/author | "Menting S.P."xsd:string |
| http://purl.uniprot.org/citations/24658504 | http://purl.uniprot.org/core/author | "Munneke J.M."xsd:string |
| http://purl.uniprot.org/citations/24658504 | http://purl.uniprot.org/core/author | "Res P.C.M."xsd:string |
| http://purl.uniprot.org/citations/24658504 | http://purl.uniprot.org/core/author | "Spuls P.I."xsd:string |
| http://purl.uniprot.org/citations/24658504 | http://purl.uniprot.org/core/author | "Te Velde A."xsd:string |
| http://purl.uniprot.org/citations/24658504 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24658504 | http://purl.uniprot.org/core/name | "J Invest Dermatol"xsd:string |
| http://purl.uniprot.org/citations/24658504 | http://purl.uniprot.org/core/pages | "2351-2360"xsd:string |
| http://purl.uniprot.org/citations/24658504 | http://purl.uniprot.org/core/title | "Composition of innate lymphoid cell subsets in the human skin: enrichment of NCR(+) ILC3 in lesional skin and blood of psoriasis patients."xsd:string |
| http://purl.uniprot.org/citations/24658504 | http://purl.uniprot.org/core/volume | "134"xsd:string |
| http://purl.uniprot.org/citations/24658504 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24658504 |
| http://purl.uniprot.org/citations/24658504 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24658504 |
| http://purl.uniprot.org/uniprot/#_O95944-mappedCitation-24658504 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24658504 |
| http://purl.uniprot.org/uniprot/O95944 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24658504 |