| http://purl.uniprot.org/citations/24662484 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24662484 | http://www.w3.org/2000/01/rdf-schema#comment | "The human 8q24 gene desert contains multiple enhancers that form tissue-specific long-range chromatin loops with the MYC oncogene, but how chromatin looping at the MYC locus is regulated remains poorly understood. Here we demonstrate that a long noncoding RNA (lncRNA), CCAT1-L, is transcribed specifically in human colorectal cancers from a locus 515 kb upstream of MYC. This lncRNA plays a role in MYC transcriptional regulation and promotes long-range chromatin looping. Importantly, the CCAT1-L locus is located within a strong super-enhancer and is spatially close to MYC. Knockdown of CCAT1-L reduced long-range interactions between the MYC promoter and its enhancers. In addition, CCAT1-L interacts with CTCF and modulates chromatin conformation at these loop regions. These results reveal an important role of a previously unannotated lncRNA in gene regulation at the MYC locus."xsd:string |
| http://purl.uniprot.org/citations/24662484 | http://purl.org/dc/terms/identifier | "doi:10.1038/cr.2014.35"xsd:string |
| http://purl.uniprot.org/citations/24662484 | http://purl.uniprot.org/core/author | "Chen T."xsd:string |
| http://purl.uniprot.org/citations/24662484 | http://purl.uniprot.org/core/author | "Ge J."xsd:string |
| http://purl.uniprot.org/citations/24662484 | http://purl.uniprot.org/core/author | "Lu X."xsd:string |
| http://purl.uniprot.org/citations/24662484 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/24662484 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/24662484 | http://purl.uniprot.org/core/author | "Yang L."xsd:string |
| http://purl.uniprot.org/citations/24662484 | http://purl.uniprot.org/core/author | "Wu Z."xsd:string |
| http://purl.uniprot.org/citations/24662484 | http://purl.uniprot.org/core/author | "Wang H.B."xsd:string |
| http://purl.uniprot.org/citations/24662484 | http://purl.uniprot.org/core/author | "Chen L.L."xsd:string |
| http://purl.uniprot.org/citations/24662484 | http://purl.uniprot.org/core/author | "Yin Q.F."xsd:string |
| http://purl.uniprot.org/citations/24662484 | http://purl.uniprot.org/core/author | "Xiang J.F."xsd:string |
| http://purl.uniprot.org/citations/24662484 | http://purl.uniprot.org/core/author | "Zhang X.O."xsd:string |
| http://purl.uniprot.org/citations/24662484 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24662484 | http://purl.uniprot.org/core/name | "Cell Res"xsd:string |
| http://purl.uniprot.org/citations/24662484 | http://purl.uniprot.org/core/pages | "513-531"xsd:string |
| http://purl.uniprot.org/citations/24662484 | http://purl.uniprot.org/core/title | "Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus."xsd:string |
| http://purl.uniprot.org/citations/24662484 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/24662484 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24662484 |
| http://purl.uniprot.org/citations/24662484 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24662484 |
| http://purl.uniprot.org/uniprot/P49711#attribution-FC8E62450743A16357FE7D84A0061A29 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24662484 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1R1-mappedCitation-24662484 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24662484 |
| http://purl.uniprot.org/uniprot/#_A0N2G3-mappedCitation-24662484 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24662484 |