| http://purl.uniprot.org/citations/24671950 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24671950 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24671950 | http://www.w3.org/2000/01/rdf-schema#comment | "Adverse environmental conditions trigger C. elegans larvae to activate an alternative developmental program, termed dauer diapause, which renders them stress resistant. High-level insulin signaling prevents constitutive dauer formation. However, it is not fully understood how animals assess conditions to choose the optimal developmental program. Here, we show that insulin-like peptide (ILP)-mediated neuron-intestine communication plays a role in this developmental decision. Consistent with, and extending, previous findings, we show that the simultaneous removal of INS-4, INS-6 and DAF-28 leads to fully penetrant constitutive dauer formation, whereas the removal of INS-1 and INS-18 significantly inhibits constitutive dauer formation. These ligands are processed by the proprotein convertases PC1/KPC-1 and/or PC2/EGL-3. The agonistic and antagonistic ligands are expressed by, and function in, neurons to prevent or promote dauer formation. By contrast, the insulin receptor DAF-2 and its effector, the FOXO transcription factor DAF-16, function solely in the intestine to regulate the decision to enter diapause. These results suggest that the nervous system normally establishes an agonistic ILP-dominant paradigm to inhibit intestinal DAF-16 activation and allow reproductive development. Under adverse conditions, a switch in the agonistic-antagonistic ILP balance activates intestinal DAF-16, which commits animals to diapause."xsd:string |
| http://purl.uniprot.org/citations/24671950 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.103846"xsd:string |
| http://purl.uniprot.org/citations/24671950 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.103846"xsd:string |
| http://purl.uniprot.org/citations/24671950 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/24671950 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/24671950 | http://purl.uniprot.org/core/author | "Chitturi J."xsd:string |
| http://purl.uniprot.org/citations/24671950 | http://purl.uniprot.org/core/author | "Chitturi J."xsd:string |
| http://purl.uniprot.org/citations/24671950 | http://purl.uniprot.org/core/author | "Zhen M."xsd:string |
| http://purl.uniprot.org/citations/24671950 | http://purl.uniprot.org/core/author | "Zhen M."xsd:string |
| http://purl.uniprot.org/citations/24671950 | http://purl.uniprot.org/core/author | "Hung W.L."xsd:string |
| http://purl.uniprot.org/citations/24671950 | http://purl.uniprot.org/core/author | "Hung W.L."xsd:string |
| http://purl.uniprot.org/citations/24671950 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24671950 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24671950 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/24671950 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/24671950 | http://purl.uniprot.org/core/pages | "1767-1779"xsd:string |
| http://purl.uniprot.org/citations/24671950 | http://purl.uniprot.org/core/pages | "1767-1779"xsd:string |
| http://purl.uniprot.org/citations/24671950 | http://purl.uniprot.org/core/title | "A Caenorhabditis elegans developmental decision requires insulin signaling-mediated neuron-intestine communication."xsd:string |
| http://purl.uniprot.org/citations/24671950 | http://purl.uniprot.org/core/title | "A Caenorhabditis elegans developmental decision requires insulin signaling-mediated neuron-intestine communication."xsd:string |
| http://purl.uniprot.org/citations/24671950 | http://purl.uniprot.org/core/volume | "141"xsd:string |
| http://purl.uniprot.org/citations/24671950 | http://purl.uniprot.org/core/volume | "141"xsd:string |
| http://purl.uniprot.org/citations/24671950 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24671950 |
| http://purl.uniprot.org/citations/24671950 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24671950 |