| http://purl.uniprot.org/citations/24674967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24674967 | http://www.w3.org/2000/01/rdf-schema#comment | "During the stress response to intense exercise, the sympathetic nervous system (SNS) induces rapid catabolism of energy reserves through the release of catecholamines and subsequent activation of protein kinase A (PKA). Paradoxically, chronic administration of sympathomimetic drugs (β-agonists) leads to anabolic adaptations in skeletal muscle, suggesting that sympathetic outflow also regulates myofiber remodeling. Here, we show that β-agonists or catecholamines released during intense exercise induce Creb-mediated transcriptional programs through activation of its obligate coactivators Crtc2 and Crtc3. In contrast to the catabolic activity normally associated with SNS function, activation of the Crtc/Creb transcriptional complex by conditional overexpression of Crtc2 in the skeletal muscle of transgenic mice fostered an anabolic state of energy and protein balance. Crtc2-overexpressing mice have increased myofiber cross-sectional area, greater intramuscular triglycerides and glycogen content. Moreover, maximal exercise capacity was enhanced after induction of Crtc2 expression in transgenic mice. Collectively these findings demonstrate that the SNS-adrenergic signaling cascade coordinates a transient catabolic stress response during high-intensity exercise, which is followed by transcriptional reprogramming that directs anabolic changes for recovery and that augments subsequent exercise performance."xsd:string |
| http://purl.uniprot.org/citations/24674967 | http://purl.org/dc/terms/identifier | "doi:10.1002/embj.201386145"xsd:string |
| http://purl.uniprot.org/citations/24674967 | http://purl.uniprot.org/core/author | "Conkright M.D."xsd:string |
| http://purl.uniprot.org/citations/24674967 | http://purl.uniprot.org/core/author | "Kelly K.A."xsd:string |
| http://purl.uniprot.org/citations/24674967 | http://purl.uniprot.org/core/author | "Nettles K.W."xsd:string |
| http://purl.uniprot.org/citations/24674967 | http://purl.uniprot.org/core/author | "Nwachukwu J.C."xsd:string |
| http://purl.uniprot.org/citations/24674967 | http://purl.uniprot.org/core/author | "Hawkins R."xsd:string |
| http://purl.uniprot.org/citations/24674967 | http://purl.uniprot.org/core/author | "Bruno N.E."xsd:string |
| http://purl.uniprot.org/citations/24674967 | http://purl.uniprot.org/core/author | "Amelio A.L."xsd:string |
| http://purl.uniprot.org/citations/24674967 | http://purl.uniprot.org/core/author | "Bramah-Lawani M."xsd:string |
| http://purl.uniprot.org/citations/24674967 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24674967 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/24674967 | http://purl.uniprot.org/core/pages | "1027-1043"xsd:string |
| http://purl.uniprot.org/citations/24674967 | http://purl.uniprot.org/core/title | "Creb coactivators direct anabolic responses and enhance performance of skeletal muscle."xsd:string |
| http://purl.uniprot.org/citations/24674967 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/24674967 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24674967 |
| http://purl.uniprot.org/citations/24674967 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24674967 |
| http://purl.uniprot.org/uniprot/Q91X84#attribution-F4AB7CF490284563EE2F5CF8DE6C724A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24674967 |
| http://purl.uniprot.org/uniprot/Q3U182#attribution-F4AB7CF490284563EE2F5CF8DE6C724A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24674967 |
| http://purl.uniprot.org/uniprot/#_F6UMS9-mappedCitation-24674967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24674967 |
| http://purl.uniprot.org/uniprot/#_F6Y626-mappedCitation-24674967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24674967 |
| http://purl.uniprot.org/uniprot/#_Q3U182-mappedCitation-24674967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24674967 |
| http://purl.uniprot.org/uniprot/#_Q3TDX5-mappedCitation-24674967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24674967 |
| http://purl.uniprot.org/uniprot/#_Q91X84-mappedCitation-24674967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24674967 |