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| http://purl.uniprot.org/citations/24677068 | http://www.w3.org/2000/01/rdf-schema#comment | "The voltage-gated sodium channel (Nav) plays a key role in regulation of neuronal excitability. Aberrant regulation of Nav expression and/or function can result in an imbalance in neuronal activity which can progress to epilepsy. Regulation of Nav activity is achieved by coordination of a multitude of mechanisms including RNA alternative splicing and translational repression. Understanding of these regulatory mechanisms is complicated by extensive genetic redundancy: the mammalian genome encodes ten Navs. By contrast, the genome of the fruitfly, Drosophila melanogaster, contains just one Nav homologue, encoded by paralytic (DmNa v ). Analysis of splicing in DmNa v shows variants exhibit distinct gating properties including varying magnitudes of persistent sodium current (INaP). Splicing by Pasilla, an identified RNA splicing factor, alters INaP magnitude as part of an activity-dependent mechanism. Enhanced INaP promotes membrane hyperexcitability that is associated with seizure-like behaviour in Drosophila. Nova-2, a mammalian Pasilla homologue, has also been linked to splicing of Navs and, moreover, mouse gene knockouts display seizure-like behaviour.Expression level of Navs is also regulated through a mechanism of translational repression in both flies and mammals. The translational repressor Pumilio (Pum) can bind to Na v transcripts and repress the normal process of translation, thus regulating sodium current (INa) density in neurons. Pum2-deficient mice exhibit spontaneous EEG abnormalities. Taken together, aberrant regulation of Nav function and/or expression is often epileptogenic. As such, a better understanding of regulation of membrane excitability through RNA alternative splicing and translational repression of Navs should provide new leads to treat epilepsy."xsd:string |
| http://purl.uniprot.org/citations/24677068 | http://purl.org/dc/terms/identifier | "doi:10.1007/s12035-014-8674-0"xsd:string |
| http://purl.uniprot.org/citations/24677068 | http://purl.uniprot.org/core/author | "Lin W.H."xsd:string |
| http://purl.uniprot.org/citations/24677068 | http://purl.uniprot.org/core/author | "Baines R.A."xsd:string |
| http://purl.uniprot.org/citations/24677068 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/24677068 | http://purl.uniprot.org/core/name | "Mol Neurobiol"xsd:string |
| http://purl.uniprot.org/citations/24677068 | http://purl.uniprot.org/core/pages | "57-67"xsd:string |
| http://purl.uniprot.org/citations/24677068 | http://purl.uniprot.org/core/title | "Regulation of membrane excitability: a convergence on voltage-gated sodium conductance."xsd:string |
| http://purl.uniprot.org/citations/24677068 | http://purl.uniprot.org/core/volume | "51"xsd:string |
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