| http://purl.uniprot.org/citations/24680683 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24680683 | http://www.w3.org/2000/01/rdf-schema#comment | "Ribosomal protein S27a (RPS27a) could perform extra-ribosomal functions besides imparting a role in ribosome biogenesis and post-translational modifications of proteins. The high expression level of RPS27a was reported in solid tumors, and we found that the expression level of RPS27a was up-regulated in advanced-phase chronic myeloid leukemia (CML) and acute leukemia (AL) patients. In this study, we explored the function of RPS27a in leukemia cells by using CML cell line K562 cells and its imatinib resistant cell line K562/G01 cells. It was observed that the expression level of RPS27a was high in K562 cells and even higher in K562/G01 cells. Further analysis revealed that RPS27a knockdown by shRNA in both K562 and K562G01 cells inhibited the cell viability, induced cell cycle arrest at S and G2/M phases and increased cell apoptosis induced by imatinib. Combination of shRNA with imatinib treatment could lead to more cleaved PARP and cleaved caspase-3 expression in RPS27a knockdown cells. Further, it was found that phospho-ERK(p-ERK) and BCL-2 were down-regulated and P21 up-regulated in RPS27a knockdown cells. In conclusion, RPS27a promotes proliferation, regulates cell cycle progression and inhibits apoptosis of leukemia cells. It appears that drugs targeting RPS27a combining with tyrosine kinase inhibitor (TKI) might represent a novel therapy strategy in TKI resistant CML patients."xsd:string |
| http://purl.uniprot.org/citations/24680683 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2014.03.086"xsd:string |
| http://purl.uniprot.org/citations/24680683 | http://purl.uniprot.org/core/author | "Chen S."xsd:string |
| http://purl.uniprot.org/citations/24680683 | http://purl.uniprot.org/core/author | "Tian Z."xsd:string |
| http://purl.uniprot.org/citations/24680683 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/24680683 | http://purl.uniprot.org/core/author | "Wang M."xsd:string |
| http://purl.uniprot.org/citations/24680683 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/24680683 | http://purl.uniprot.org/core/author | "Yu J."xsd:string |
| http://purl.uniprot.org/citations/24680683 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/24680683 | http://purl.uniprot.org/core/author | "Wei H."xsd:string |
| http://purl.uniprot.org/citations/24680683 | http://purl.uniprot.org/core/author | "Xiong Y."xsd:string |
| http://purl.uniprot.org/citations/24680683 | http://purl.uniprot.org/core/author | "Xing H."xsd:string |
| http://purl.uniprot.org/citations/24680683 | http://purl.uniprot.org/core/author | "Tang K."xsd:string |
| http://purl.uniprot.org/citations/24680683 | http://purl.uniprot.org/core/author | "Rao Q."xsd:string |
| http://purl.uniprot.org/citations/24680683 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24680683 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/24680683 | http://purl.uniprot.org/core/pages | "1204-1210"xsd:string |
| http://purl.uniprot.org/citations/24680683 | http://purl.uniprot.org/core/title | "RPS27a promotes proliferation, regulates cell cycle progression and inhibits apoptosis of leukemia cells."xsd:string |
| http://purl.uniprot.org/citations/24680683 | http://purl.uniprot.org/core/volume | "446"xsd:string |
| http://purl.uniprot.org/citations/24680683 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24680683 |
| http://purl.uniprot.org/citations/24680683 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24680683 |
| http://purl.uniprot.org/uniprot/#_A0A248RGE3-mappedCitation-24680683 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24680683 |
| http://purl.uniprot.org/uniprot/#_A8CGI2-mappedCitation-24680683 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24680683 |
| http://purl.uniprot.org/uniprot/#_B2RDW1-mappedCitation-24680683 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24680683 |