| http://purl.uniprot.org/citations/24681597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24681597 | http://www.w3.org/2000/01/rdf-schema#comment | "Kindlin-1 is an integrin tail binding protein that controls integrin activation. Mutations in the FERMT-1 gene, which encodes for Kindlin-1, lead to Kindler syndrome in man, which is characterized by skin blistering, premature skin aging and skin cancer of unknown etiology. Here we show that loss of Kindlin-1 in mouse keratinocytes recapitulates Kindler syndrome and also produces enlarged and hyperactive stem cell compartments, which lead to hyperthickened epidermis, ectopic hair follicle development and increased skin tumor susceptibility. Mechanistically, Kindlin-1 controls keratinocyte adhesion through β1-class integrins and proliferation and differentiation of cutaneous epithelial stem cells by promoting α(v)β(6) integrin-mediated transforming growth factor-β (TGF-β) activation and inhibiting Wnt-β-catenin signaling through integrin-independent regulation of Wnt ligand expression. Our findings assign Kindlin-1 the previously unknown and essential task of controlling cutaneous epithelial stem cell homeostasis by balancing TGF-β-mediated growth-inhibitory signals and Wnt-β-catenin-mediated growth-promoting signals."xsd:string |
| http://purl.uniprot.org/citations/24681597 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm.3490"xsd:string |
| http://purl.uniprot.org/citations/24681597 | http://purl.uniprot.org/core/author | "McGrath J.A."xsd:string |
| http://purl.uniprot.org/citations/24681597 | http://purl.uniprot.org/core/author | "Ussar S."xsd:string |
| http://purl.uniprot.org/citations/24681597 | http://purl.uniprot.org/core/author | "Lai-Cheong J.E."xsd:string |
| http://purl.uniprot.org/citations/24681597 | http://purl.uniprot.org/core/author | "Fassler R."xsd:string |
| http://purl.uniprot.org/citations/24681597 | http://purl.uniprot.org/core/author | "Ruppert R."xsd:string |
| http://purl.uniprot.org/citations/24681597 | http://purl.uniprot.org/core/author | "Rifkin D.B."xsd:string |
| http://purl.uniprot.org/citations/24681597 | http://purl.uniprot.org/core/author | "Rognoni E."xsd:string |
| http://purl.uniprot.org/citations/24681597 | http://purl.uniprot.org/core/author | "Widmaier M."xsd:string |
| http://purl.uniprot.org/citations/24681597 | http://purl.uniprot.org/core/author | "Bottcher R.T."xsd:string |
| http://purl.uniprot.org/citations/24681597 | http://purl.uniprot.org/core/author | "Jakobson M."xsd:string |
| http://purl.uniprot.org/citations/24681597 | http://purl.uniprot.org/core/author | "Katsougkri D."xsd:string |
| http://purl.uniprot.org/citations/24681597 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24681597 | http://purl.uniprot.org/core/name | "Nat Med"xsd:string |
| http://purl.uniprot.org/citations/24681597 | http://purl.uniprot.org/core/pages | "350-359"xsd:string |
| http://purl.uniprot.org/citations/24681597 | http://purl.uniprot.org/core/title | "Kindlin-1 controls Wnt and TGF-beta availability to regulate cutaneous stem cell proliferation."xsd:string |
| http://purl.uniprot.org/citations/24681597 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/24681597 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24681597 |
| http://purl.uniprot.org/citations/24681597 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24681597 |
| http://purl.uniprot.org/uniprot/Q02248#attribution-E1E57C65F182F64064C44DC10A148BEE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24681597 |
| http://purl.uniprot.org/uniprot/P59113#attribution-58E48AB51E82B29ABF9DF9B5BDB8897A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24681597 |
| http://purl.uniprot.org/uniprot/Q9Z0T9#attribution-E1E57C65F182F64064C44DC10A148BEE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24681597 |
| http://purl.uniprot.org/uniprot/P09055#attribution-58E48AB51E82B29ABF9DF9B5BDB8897A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24681597 |