http://purl.uniprot.org/citations/24684830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/24684830 | http://www.w3.org/2000/01/rdf-schema#comment | "The eukaryotic cell cycle, driven by both transcriptional and posttranslational mechanisms, is the central molecular oscillator underlying tissue growth throughout animals. Although genome-wide studies have investigated cell-cycle-associated transcription in unicellular systems, global patterns of periodic transcription in multicellular tissues remain largely unexplored. Here we define the cell-cycle-associated transcriptome of the developing Drosophila wing epithelium and compare it with that of cultured Drosophila S2 cells, revealing a core set of periodic genes and a surprising degree of context specificity in periodic transcription. We further employ RNAi-mediated phenotypic profiling to define functional requirements for more than 300 periodic genes, with a focus on those required for cell proliferation in vivo. Finally, we investigate uncharacterized genes required for interkinetic nuclear migration. Combined, these findings provide a global perspective on cell-cycle control in vivo, and they highlight a critical need to understand the context-specific regulation of cell proliferation."xsd:string |
http://purl.uniprot.org/citations/24684830 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2014.02.018"xsd:string |
http://purl.uniprot.org/citations/24684830 | http://purl.uniprot.org/core/author | "Liang L."xsd:string |
http://purl.uniprot.org/citations/24684830 | http://purl.uniprot.org/core/author | "Gibson M.C."xsd:string |
http://purl.uniprot.org/citations/24684830 | http://purl.uniprot.org/core/author | "Seidel C.W."xsd:string |
http://purl.uniprot.org/citations/24684830 | http://purl.uniprot.org/core/author | "Haug J.S."xsd:string |
http://purl.uniprot.org/citations/24684830 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
http://purl.uniprot.org/citations/24684830 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
http://purl.uniprot.org/citations/24684830 | http://purl.uniprot.org/core/pages | "112-127"xsd:string |
http://purl.uniprot.org/citations/24684830 | http://purl.uniprot.org/core/title | "Functional genomic analysis of the periodic transcriptome in the developing Drosophila wing."xsd:string |
http://purl.uniprot.org/citations/24684830 | http://purl.uniprot.org/core/volume | "29"xsd:string |
http://purl.uniprot.org/citations/24684830 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24684830 |
http://purl.uniprot.org/citations/24684830 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24684830 |
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http://purl.uniprot.org/uniprot/#_A0A0B4KHN3-mappedCitation-24684830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24684830 |
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http://purl.uniprot.org/uniprot/#_D0IQG7-mappedCitation-24684830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24684830 |
http://purl.uniprot.org/uniprot/#_A0A0C4DHE7-mappedCitation-24684830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24684830 |
http://purl.uniprot.org/uniprot/#_A0A0B4KI37-mappedCitation-24684830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24684830 |
http://purl.uniprot.org/uniprot/#_A0A0B4KI54-mappedCitation-24684830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24684830 |
http://purl.uniprot.org/uniprot/#_A0A0B4LEV2-mappedCitation-24684830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24684830 |