| http://purl.uniprot.org/citations/24684932 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24684932 | http://www.w3.org/2000/01/rdf-schema#comment | "More than 2,000 C. elegans genes are targeted for RNA silencing by the mutator complex, a specialized small interfering RNA (siRNA) amplification module which is nucleated by the Q/N-rich protein MUT-16. The mutator complex localizes to Mutator foci adjacent to P granules at the nuclear periphery in germ cells. Here, we show that the DEAD box RNA helicase smut-1 functions redundantly in the mutator pathway with its paralog mut-14 during RNAi. Mutations in both smut-1 and mut-14 also cause widespread loss of endogenous siRNAs. The targets of mut-14 and smut-1 largely overlap with the targets of other mutator class genes; however, the mut-14 smut-1 double mutant and the mut-16 mutant display the most dramatic depletion of siRNAs, suggesting that they act at a similarly early step in siRNA formation. mut-14 and smut-1 are predominantly expressed in the germline and, unlike other mutator class genes, are specifically required for RNAi targeting germline genes. A catalytically inactive, dominant-negative missense mutant of MUT-14 is RNAi defective in vivo; however, mutator complexes containing the mutant protein retain the ability to synthesize siRNAs in vitro. The results point to a role for mut-14 and smut-1 in initiating siRNA amplification in germ cell Mutator foci, possibly through the recruitment or retention of target mRNAs."xsd:string |
| http://purl.uniprot.org/citations/24684932 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2014.02.060"xsd:string |
| http://purl.uniprot.org/citations/24684932 | http://purl.uniprot.org/core/author | "Ketting R.F."xsd:string |
| http://purl.uniprot.org/citations/24684932 | http://purl.uniprot.org/core/author | "Montgomery T.A."xsd:string |
| http://purl.uniprot.org/citations/24684932 | http://purl.uniprot.org/core/author | "Phillips C.M."xsd:string |
| http://purl.uniprot.org/citations/24684932 | http://purl.uniprot.org/core/author | "Newman M.A."xsd:string |
| http://purl.uniprot.org/citations/24684932 | http://purl.uniprot.org/core/author | "Ruvkun G."xsd:string |
| http://purl.uniprot.org/citations/24684932 | http://purl.uniprot.org/core/author | "Roovers E.F."xsd:string |
| http://purl.uniprot.org/citations/24684932 | http://purl.uniprot.org/core/author | "Ohsumi T.K."xsd:string |
| http://purl.uniprot.org/citations/24684932 | http://purl.uniprot.org/core/author | "Rim Y.S."xsd:string |
| http://purl.uniprot.org/citations/24684932 | http://purl.uniprot.org/core/author | "Breen P.C."xsd:string |
| http://purl.uniprot.org/citations/24684932 | http://purl.uniprot.org/core/author | "van Wolfswinkel J.C."xsd:string |
| http://purl.uniprot.org/citations/24684932 | http://purl.uniprot.org/core/author | "Montgomery B.E."xsd:string |
| http://purl.uniprot.org/citations/24684932 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24684932 | http://purl.uniprot.org/core/name | "Curr Biol"xsd:string |
| http://purl.uniprot.org/citations/24684932 | http://purl.uniprot.org/core/pages | "839-844"xsd:string |
| http://purl.uniprot.org/citations/24684932 | http://purl.uniprot.org/core/title | "MUT-14 and SMUT-1 DEAD box RNA helicases have overlapping roles in germline RNAi and endogenous siRNA formation."xsd:string |
| http://purl.uniprot.org/citations/24684932 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/24684932 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24684932 |
| http://purl.uniprot.org/citations/24684932 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24684932 |
| http://purl.uniprot.org/uniprot/P34607#attribution-E1E9EF9B27ABFED28D55E027A70D50C3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24684932 |
| http://purl.uniprot.org/uniprot/G5ECM1#attribution-E1E9EF9B27ABFED28D55E027A70D50C3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24684932 |
| http://purl.uniprot.org/uniprot/Q17978#attribution-BB720B74072943E310BE92C455A9C511 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24684932 |
| http://purl.uniprot.org/uniprot/Q17978#attribution-E1E9EF9B27ABFED28D55E027A70D50C3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24684932 |