| http://purl.uniprot.org/citations/24688028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24688028 | http://www.w3.org/2000/01/rdf-schema#comment | "Upon TCR restimulation, activated, cycling T cells can undergo a self-regulatory form of apoptosis known as restimulation-induced cell death (RICD). We previously demonstrated that RICD is impaired in T cells from patients with X-linked lymphoproliferative disease, which lack SLAM-associated protein (SAP) expression. Both SAP and the specific SLAM receptor NK, T, and B cell Ag (NTB-A) are required for RICD, but the mechanism by which these molecules promote a strong, proapoptotic signal through the TCR remains unclear. In this article, we show that the Src-family kinase LCK, but not FYN, associates with NTB-A in activated human T cells. This association increased after TCR restimulation in a SAP-dependent manner, requiring both immunoreceptor tyrosine-based switch motifs in the NTB-A cytoplasmic tail. Both NTB-A-associated LCK phosphorylation and kinase activity were enhanced in restimulated T cells, amplifying proximal TCR signaling. In contrast, TCR-induced LCK association with NTB-A, as well as phosphorylation and kinase activity, was reduced in T cells from patients with X-linked lymphoproliferative disease or normal T cells transfected with SAP-specific small interfering RNA, consistent with RICD resistance. Collectively, our data reveal how SAP nucleates a previously unknown signaling complex involving NTB-A and LCK to potentiate RICD of activated human T cells."xsd:string |
| http://purl.uniprot.org/citations/24688028 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1303070"xsd:string |
| http://purl.uniprot.org/citations/24688028 | http://purl.uniprot.org/core/author | "Katz G."xsd:string |
| http://purl.uniprot.org/citations/24688028 | http://purl.uniprot.org/core/author | "Snow A.L."xsd:string |
| http://purl.uniprot.org/citations/24688028 | http://purl.uniprot.org/core/author | "Stinson J.R."xsd:string |
| http://purl.uniprot.org/citations/24688028 | http://purl.uniprot.org/core/author | "Larsen S.E."xsd:string |
| http://purl.uniprot.org/citations/24688028 | http://purl.uniprot.org/core/author | "Krummey S.M."xsd:string |
| http://purl.uniprot.org/citations/24688028 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24688028 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/24688028 | http://purl.uniprot.org/core/pages | "4202-4209"xsd:string |
| http://purl.uniprot.org/citations/24688028 | http://purl.uniprot.org/core/title | "SAP facilitates recruitment and activation of LCK at NTB-A receptors during restimulation-induced cell death."xsd:string |
| http://purl.uniprot.org/citations/24688028 | http://purl.uniprot.org/core/volume | "192"xsd:string |
| http://purl.uniprot.org/citations/24688028 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24688028 |
| http://purl.uniprot.org/citations/24688028 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24688028 |
| http://purl.uniprot.org/uniprot/#_E9PJ92-mappedCitation-24688028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24688028 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3T3-mappedCitation-24688028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24688028 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3Y8-mappedCitation-24688028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24688028 |
| http://purl.uniprot.org/uniprot/#_A0A8V8TLH8-mappedCitation-24688028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24688028 |
| http://purl.uniprot.org/uniprot/#_B3KUV3-mappedCitation-24688028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24688028 |
| http://purl.uniprot.org/uniprot/#_B4DZS7-mappedCitation-24688028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24688028 |
| http://purl.uniprot.org/uniprot/#_B4E1U5-mappedCitation-24688028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24688028 |
| http://purl.uniprot.org/uniprot/#_B7Z6A7-mappedCitation-24688028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24688028 |
| http://purl.uniprot.org/uniprot/#_K7YQB3-mappedCitation-24688028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24688028 |
| http://purl.uniprot.org/uniprot/#_P06239-mappedCitation-24688028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24688028 |