| http://purl.uniprot.org/citations/24692546 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24692546 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24692546 | http://www.w3.org/2000/01/rdf-schema#comment | "Follicle-stimulating hormone receptor (FSHR), a G-protein coupled receptor, is an important drug target in the development of novel therapeutics for reproductive indications. The FSHR extracellular domains were observed in the crystal structure as a trimer, which enabled us to propose a novel model for the receptor activation mechanism. The model predicts that FSHR binds Asnα(52)-deglycosylated FSH at a 3-fold higher capacity than fully glycosylated FSH. It also predicts that, upon dissociation of the FSHR trimer into monomers, the binding of glycosylated FSH, but not deglycosylated FSH, would increase 3-fold, and that the dissociated monomers would in turn enhance FSHR binding and signaling activities by 3-fold. This study presents evidence confirming these predictions and provides crystallographic and mutagenesis data supporting the proposed model. The model also provides a mechanistic explanation to the agonist and antagonist activities of thyroid-stimulating hormone receptor autoantibodies. We conclude that FSHR exists as a functional trimer."xsd:string |
| http://purl.uniprot.org/citations/24692546 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m114.549592"xsd:string |
| http://purl.uniprot.org/citations/24692546 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m114.549592"xsd:string |
| http://purl.uniprot.org/citations/24692546 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/24692546 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/24692546 | http://purl.uniprot.org/core/author | "He X."xsd:string |
| http://purl.uniprot.org/citations/24692546 | http://purl.uniprot.org/core/author | "He X."xsd:string |
| http://purl.uniprot.org/citations/24692546 | http://purl.uniprot.org/core/author | "Jiang X."xsd:string |
| http://purl.uniprot.org/citations/24692546 | http://purl.uniprot.org/core/author | "Jiang X."xsd:string |
| http://purl.uniprot.org/citations/24692546 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/24692546 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/24692546 | http://purl.uniprot.org/core/author | "Fischer D."xsd:string |
| http://purl.uniprot.org/citations/24692546 | http://purl.uniprot.org/core/author | "Fischer D."xsd:string |
| http://purl.uniprot.org/citations/24692546 | http://purl.uniprot.org/core/author | "Arkinstall S."xsd:string |
| http://purl.uniprot.org/citations/24692546 | http://purl.uniprot.org/core/author | "Arkinstall S."xsd:string |
| http://purl.uniprot.org/citations/24692546 | http://purl.uniprot.org/core/author | "Goutopoulos A."xsd:string |
| http://purl.uniprot.org/citations/24692546 | http://purl.uniprot.org/core/author | "Goutopoulos A."xsd:string |
| http://purl.uniprot.org/citations/24692546 | http://purl.uniprot.org/core/author | "McKenna S.D."xsd:string |
| http://purl.uniprot.org/citations/24692546 | http://purl.uniprot.org/core/author | "McKenna S.D."xsd:string |
| http://purl.uniprot.org/citations/24692546 | http://purl.uniprot.org/core/author | "Sriraman V."xsd:string |
| http://purl.uniprot.org/citations/24692546 | http://purl.uniprot.org/core/author | "Sriraman V."xsd:string |
| http://purl.uniprot.org/citations/24692546 | http://purl.uniprot.org/core/author | "Yu H.N."xsd:string |
| http://purl.uniprot.org/citations/24692546 | http://purl.uniprot.org/core/author | "Yu H.N."xsd:string |