| http://purl.uniprot.org/citations/24695785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24695785 | http://www.w3.org/2000/01/rdf-schema#comment | "The transient receptor potential family V1 channel (TRPV1) is activated by multiple stimuli, including capsaicin, acid, endovanilloids, and heat (>42C). Post-translational modifications to TRPV1 result in dynamic changes to the sensitivity of receptor activation. We have previously demonstrated that β-arrestin2 actively participates in a scaffolding mechanism to inhibit TRPV1 phosphorylation, thereby reducing TRPV1 sensitivity. In this study, we evaluated the effect of β-arrestin2 sequestration by G-protein coupled receptors (GPCRs) on thermal and chemical activation of TRPV1. Here we report that activation of mu opioid receptor by either morphine or DAMGO results in β-arrestin2 recruitment to mu opioid receptor in sensory neurons, while activation by herkinorin does not. Furthermore, treatment of sensory neurons with morphine or DAMGO stimulates β-arrestin2 dissociation from TRPV1 and increased sensitivity of the receptor. Conversely, herkinorin treatment has no effect on TRPV1 sensitivity. Additional behavioral studies indicate that GPCR-driven β-arrestin2 sequestration plays an important peripheral role in the development of thermal sensitivity. Taken together, the reported data identify a novel cross-talk mechanism between GPCRs and TRPV1 that may contribute to multiple clinical conditions."xsd:string |
| http://purl.uniprot.org/citations/24695785 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0093688"xsd:string |
| http://purl.uniprot.org/citations/24695785 | http://purl.uniprot.org/core/author | "Gomez R."xsd:string |
| http://purl.uniprot.org/citations/24695785 | http://purl.uniprot.org/core/author | "Bunnett N.W."xsd:string |
| http://purl.uniprot.org/citations/24695785 | http://purl.uniprot.org/core/author | "Szteyn K."xsd:string |
| http://purl.uniprot.org/citations/24695785 | http://purl.uniprot.org/core/author | "Bierbower S.M."xsd:string |
| http://purl.uniprot.org/citations/24695785 | http://purl.uniprot.org/core/author | "Jeske N.A."xsd:string |
| http://purl.uniprot.org/citations/24695785 | http://purl.uniprot.org/core/author | "Veldhuis N."xsd:string |
| http://purl.uniprot.org/citations/24695785 | http://purl.uniprot.org/core/author | "Rowan M.P."xsd:string |
| http://purl.uniprot.org/citations/24695785 | http://purl.uniprot.org/core/author | "Por E.D."xsd:string |
| http://purl.uniprot.org/citations/24695785 | http://purl.uniprot.org/core/author | "Eskander M.A."xsd:string |
| http://purl.uniprot.org/citations/24695785 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24695785 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/24695785 | http://purl.uniprot.org/core/pages | "e93688"xsd:string |
| http://purl.uniprot.org/citations/24695785 | http://purl.uniprot.org/core/title | "Activation of mu opioid receptors sensitizes transient receptor potential vanilloid type 1 (TRPV1) via beta-arrestin-2-mediated cross-talk."xsd:string |
| http://purl.uniprot.org/citations/24695785 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/24695785 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24695785 |
| http://purl.uniprot.org/citations/24695785 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24695785 |
| http://purl.uniprot.org/uniprot/#_A0A0G3VLX9-mappedCitation-24695785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24695785 |
| http://purl.uniprot.org/uniprot/#_A0A158SIT9-mappedCitation-24695785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24695785 |
| http://purl.uniprot.org/uniprot/#_J3JS97-mappedCitation-24695785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24695785 |
| http://purl.uniprot.org/uniprot/#_Q3TRC8-mappedCitation-24695785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24695785 |
| http://purl.uniprot.org/uniprot/#_Q3UCU5-mappedCitation-24695785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24695785 |
| http://purl.uniprot.org/uniprot/#_Q704Y3-mappedCitation-24695785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24695785 |