| http://purl.uniprot.org/citations/24698274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24698274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24698274 | http://www.w3.org/2000/01/rdf-schema#comment | "Peptide neuromodulators are released from a unique organelle: the dense-core vesicle. Dense-core vesicles are generated at the trans-Golgi and then sort cargo during maturation before being secreted. To identify proteins that act in this pathway, we performed a genetic screen in Caenorhabditis elegans for mutants defective in dense-core vesicle function. We identified two conserved Rab2-binding proteins: RUND-1, a RUN domain protein, and CCCP-1, a coiled-coil protein. RUND-1 and CCCP-1 colocalize with RAB-2 at the Golgi, and rab-2, rund-1, and cccp-1 mutants have similar defects in sorting soluble and transmembrane dense-core vesicle cargos. RUND-1 also interacts with the Rab2 GAP protein TBC-8 and the BAR domain protein RIC-19, a RAB-2 effector. In summary, a pathway of conserved proteins controls the maturation of dense-core vesicles at the trans-Golgi network."xsd:string |
| http://purl.uniprot.org/citations/24698274 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2014.02.017"xsd:string |
| http://purl.uniprot.org/citations/24698274 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2014.02.017"xsd:string |
| http://purl.uniprot.org/citations/24698274 | http://purl.uniprot.org/core/author | "Gu M."xsd:string |
| http://purl.uniprot.org/citations/24698274 | http://purl.uniprot.org/core/author | "Gu M."xsd:string |
| http://purl.uniprot.org/citations/24698274 | http://purl.uniprot.org/core/author | "Liu Q."xsd:string |
| http://purl.uniprot.org/citations/24698274 | http://purl.uniprot.org/core/author | "Liu Q."xsd:string |
| http://purl.uniprot.org/citations/24698274 | http://purl.uniprot.org/core/author | "Watanabe S."xsd:string |
| http://purl.uniprot.org/citations/24698274 | http://purl.uniprot.org/core/author | "Watanabe S."xsd:string |
| http://purl.uniprot.org/citations/24698274 | http://purl.uniprot.org/core/author | "Hegermann J."xsd:string |
| http://purl.uniprot.org/citations/24698274 | http://purl.uniprot.org/core/author | "Hegermann J."xsd:string |
| http://purl.uniprot.org/citations/24698274 | http://purl.uniprot.org/core/author | "Jorgensen E.M."xsd:string |
| http://purl.uniprot.org/citations/24698274 | http://purl.uniprot.org/core/author | "Jorgensen E.M."xsd:string |
| http://purl.uniprot.org/citations/24698274 | http://purl.uniprot.org/core/author | "Ailion M."xsd:string |
| http://purl.uniprot.org/citations/24698274 | http://purl.uniprot.org/core/author | "Ailion M."xsd:string |
| http://purl.uniprot.org/citations/24698274 | http://purl.uniprot.org/core/author | "Dalton S."xsd:string |
| http://purl.uniprot.org/citations/24698274 | http://purl.uniprot.org/core/author | "Dalton S."xsd:string |
| http://purl.uniprot.org/citations/24698274 | http://purl.uniprot.org/core/author | "Eimer S."xsd:string |
| http://purl.uniprot.org/citations/24698274 | http://purl.uniprot.org/core/author | "Eimer S."xsd:string |
| http://purl.uniprot.org/citations/24698274 | http://purl.uniprot.org/core/author | "Hannemann M."xsd:string |
| http://purl.uniprot.org/citations/24698274 | http://purl.uniprot.org/core/author | "Hannemann M."xsd:string |
| http://purl.uniprot.org/citations/24698274 | http://purl.uniprot.org/core/author | "Sasidharan N."xsd:string |
| http://purl.uniprot.org/citations/24698274 | http://purl.uniprot.org/core/author | "Sasidharan N."xsd:string |