| http://purl.uniprot.org/citations/24699451 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24699451 | http://www.w3.org/2000/01/rdf-schema#comment | "TH1 and TH17 cells mediate neuroinflammation in experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. Pathogenic TH cells in EAE must produce the pro-inflammatory cytokine granulocyte-macrophage colony stimulating factor (GM-CSF). TH cell pathogenicity in EAE is also regulated by cell-intrinsic production of the immunosuppressive cytokine interleukin 10 (IL-10). Here we demonstrate that mice deficient for the basic helix-loop-helix (bHLH) transcription factor Bhlhe40 (Bhlhe40(-/-)) are resistant to the induction of EAE. Bhlhe40 is required in vivo in a T cell-intrinsic manner, where it positively regulates the production of GM-CSF and negatively regulates the production of IL-10. In vitro, GM-CSF secretion is selectively abrogated in polarized Bhlhe40(-/-) TH1 and TH17 cells, and these cells show increased production of IL-10. Blockade of IL-10 receptor in Bhlhe40(-/-) mice renders them susceptible to EAE. These findings identify Bhlhe40 as a critical regulator of autoreactive T-cell pathogenicity."xsd:string |
| http://purl.uniprot.org/citations/24699451 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms4551"xsd:string |
| http://purl.uniprot.org/citations/24699451 | http://purl.uniprot.org/core/author | "Cook L.E."xsd:string |
| http://purl.uniprot.org/citations/24699451 | http://purl.uniprot.org/core/author | "Carrero J.A."xsd:string |
| http://purl.uniprot.org/citations/24699451 | http://purl.uniprot.org/core/author | "Egawa T."xsd:string |
| http://purl.uniprot.org/citations/24699451 | http://purl.uniprot.org/core/author | "Lin C.C."xsd:string |
| http://purl.uniprot.org/citations/24699451 | http://purl.uniprot.org/core/author | "Bradstreet T.R."xsd:string |
| http://purl.uniprot.org/citations/24699451 | http://purl.uniprot.org/core/author | "Edelson B.T."xsd:string |
| http://purl.uniprot.org/citations/24699451 | http://purl.uniprot.org/core/author | "Murphy T.L."xsd:string |
| http://purl.uniprot.org/citations/24699451 | http://purl.uniprot.org/core/author | "Russell J.H."xsd:string |
| http://purl.uniprot.org/citations/24699451 | http://purl.uniprot.org/core/author | "Sim J."xsd:string |
| http://purl.uniprot.org/citations/24699451 | http://purl.uniprot.org/core/author | "Taneja R."xsd:string |
| http://purl.uniprot.org/citations/24699451 | http://purl.uniprot.org/core/author | "Chou C."xsd:string |
| http://purl.uniprot.org/citations/24699451 | http://purl.uniprot.org/core/author | "Schwarzkopf E.A."xsd:string |
| http://purl.uniprot.org/citations/24699451 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24699451 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/24699451 | http://purl.uniprot.org/core/pages | "3551"xsd:string |
| http://purl.uniprot.org/citations/24699451 | http://purl.uniprot.org/core/title | "Bhlhe40 controls cytokine production by T cells and is essential for pathogenicity in autoimmune neuroinflammation."xsd:string |
| http://purl.uniprot.org/citations/24699451 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/24699451 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24699451 |
| http://purl.uniprot.org/citations/24699451 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24699451 |
| http://purl.uniprot.org/uniprot/#_B3VI66-mappedCitation-24699451 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24699451 |
| http://purl.uniprot.org/uniprot/#_E9Q2C3-mappedCitation-24699451 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24699451 |
| http://purl.uniprot.org/uniprot/#_Q14AD9-mappedCitation-24699451 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24699451 |