| http://purl.uniprot.org/citations/24704450 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24704450 | http://www.w3.org/2000/01/rdf-schema#comment | "The molecular mechanisms of multiple myeloma are not well defined. EEN is an endocytosis-regulating molecule. Here we report that EEN regulates the proliferation and survival of multiple myeloma cells, by regulating IGF-1 secretion. In the present study, we observed that EEN expression paralleled with cell proliferation, EEN accelerated cell proliferation, facilitated cell cycle transition from G1 to S phase by regulating cyclin-dependent kinases (CDKs) pathway, and delayed cell apoptosis via Bcl2/Bax-mitochondrial pathway. Mechanistically, we found that EEN was indispensable for insulin-like growth factor-1 (IGF-1) secretion and the activation of protein kinase B-mammalian target of rapamycin (Akt-mTOR) pathway. Exogenous IGF-1 overcame the phenotype of EEN depletion, while IGF-1 neutralization overcame that of EEN over-expression. Collectively, these data suggest that EEN may play a pivotal role in excessive cell proliferation and insufficient cell apoptosis of bone marrow plasma cells in multiple myeloma. Therefore, EEN may represent a potential diagnostic marker or therapeutic target for multiple myeloma."xsd:string |
| http://purl.uniprot.org/citations/24704450 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2014.03.127"xsd:string |
| http://purl.uniprot.org/citations/24704450 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/24704450 | http://purl.uniprot.org/core/author | "Liu C."xsd:string |
| http://purl.uniprot.org/citations/24704450 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/24704450 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/24704450 | http://purl.uniprot.org/core/author | "Shi H."xsd:string |
| http://purl.uniprot.org/citations/24704450 | http://purl.uniprot.org/core/author | "Chen X.H."xsd:string |
| http://purl.uniprot.org/citations/24704450 | http://purl.uniprot.org/core/author | "Li X.Y."xsd:string |
| http://purl.uniprot.org/citations/24704450 | http://purl.uniprot.org/core/author | "Liu C.H."xsd:string |
| http://purl.uniprot.org/citations/24704450 | http://purl.uniprot.org/core/author | "Xu S.W."xsd:string |
| http://purl.uniprot.org/citations/24704450 | http://purl.uniprot.org/core/author | "Zheng J.X."xsd:string |
| http://purl.uniprot.org/citations/24704450 | http://purl.uniprot.org/core/author | "Li Z.G."xsd:string |
| http://purl.uniprot.org/citations/24704450 | http://purl.uniprot.org/core/author | "Cheng J.D."xsd:string |
| http://purl.uniprot.org/citations/24704450 | http://purl.uniprot.org/core/author | "Huang E.W."xsd:string |
| http://purl.uniprot.org/citations/24704450 | http://purl.uniprot.org/core/author | "Lv G.L."xsd:string |
| http://purl.uniprot.org/citations/24704450 | http://purl.uniprot.org/core/author | "Xue S.J."xsd:string |
| http://purl.uniprot.org/citations/24704450 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24704450 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/24704450 | http://purl.uniprot.org/core/pages | "271-277"xsd:string |
| http://purl.uniprot.org/citations/24704450 | http://purl.uniprot.org/core/title | "EEN regulates the proliferation and survival of multiple myeloma cells by potentiating IGF-1 secretion."xsd:string |
| http://purl.uniprot.org/citations/24704450 | http://purl.uniprot.org/core/volume | "447"xsd:string |
| http://purl.uniprot.org/citations/24704450 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24704450 |
| http://purl.uniprot.org/citations/24704450 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24704450 |