| http://purl.uniprot.org/citations/24705551 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24705551 | http://www.w3.org/2000/01/rdf-schema#comment | "The plasma membrane contributes to the formation of autophagosomes, the double-membrane vesicles that sequester cytosolic cargo and deliver it to lysosomes for degradation during autophagy. In this study, we have identified a regulatory role for connexins (Cx), the main components of plasma membrane gap junctions, in autophagosome formation. We have found that plasma-membrane-localized Cx proteins constitutively downregulate autophagy through a direct interaction with several autophagy-related proteins involved in the initial steps of autophagosome formation, such as Atg16 and components of the PI(3)K autophagy initiation complex (Vps34, Beclin-1 and Vps15). On nutrient starvation, this inhibitory effect is released by the arrival of Atg14 to the Cx-Atg complex. This promotes the internalization of Cx-Atg along with Atg9, which is also recruited to the plasma membrane in response to starvation. Maturation of the Cx-containing pre-autophagosomes into autophagosomes leads to degradation of these endogenous inhibitors, allowing for sustained activation of autophagy."xsd:string |
| http://purl.uniprot.org/citations/24705551 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb2934"xsd:string |
| http://purl.uniprot.org/citations/24705551 | http://purl.uniprot.org/core/author | "Patel B."xsd:string |
| http://purl.uniprot.org/citations/24705551 | http://purl.uniprot.org/core/author | "Cuervo A.M."xsd:string |
| http://purl.uniprot.org/citations/24705551 | http://purl.uniprot.org/core/author | "Spray D.C."xsd:string |
| http://purl.uniprot.org/citations/24705551 | http://purl.uniprot.org/core/author | "Yuste A."xsd:string |
| http://purl.uniprot.org/citations/24705551 | http://purl.uniprot.org/core/author | "Bejarano E."xsd:string |
| http://purl.uniprot.org/citations/24705551 | http://purl.uniprot.org/core/author | "Stout R.F. Jr."xsd:string |
| http://purl.uniprot.org/citations/24705551 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24705551 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/24705551 | http://purl.uniprot.org/core/pages | "401-414"xsd:string |
| http://purl.uniprot.org/citations/24705551 | http://purl.uniprot.org/core/title | "Connexins modulate autophagosome biogenesis."xsd:string |
| http://purl.uniprot.org/citations/24705551 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/24705551 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24705551 |
| http://purl.uniprot.org/citations/24705551 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24705551 |
| http://purl.uniprot.org/uniprot/#_A0A087WQR4-mappedCitation-24705551 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24705551 |
| http://purl.uniprot.org/uniprot/#_A0A087WP62-mappedCitation-24705551 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24705551 |
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| http://purl.uniprot.org/uniprot/#_A0A385JBX3-mappedCitation-24705551 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24705551 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P8A3-mappedCitation-24705551 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24705551 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BQC2-mappedCitation-24705551 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24705551 |
| http://purl.uniprot.org/uniprot/#_B2RY05-mappedCitation-24705551 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24705551 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P793-mappedCitation-24705551 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24705551 |
| http://purl.uniprot.org/uniprot/#_A0A654ICD2-mappedCitation-24705551 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24705551 |