| http://purl.uniprot.org/citations/24710520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24710520 | http://www.w3.org/2000/01/rdf-schema#comment | "Osteocytes express multiple genes involved in mineral metabolism including PHEX, FGF23, DMP1 and FAM20C. In Hyp mice, a murine model for X-linked hypophosphatemia (XLH), Phex deficiency results in the overproduction of FGF23 in osteocytes, which leads to hypophosphatemia and impaired vitamin D metabolism. In this study, to further clarify the abnormality in osteocytes of Hyp mice, we obtained detailed gene expression profiles in osteoblasts and osteocytes isolated from the long bones of 20-week-old Hyp mice and wild-type (WT) control mice. The expression of Fgf23, Dmp1, and Fam20c was higher in osteocytic cells than in osteoblastic cells in both genotypes, and was up-regulated in Hyp cells. Interestingly, the up-regulation of these genes in Hyp bones began before birth. On the other hand, the expression of Slc20a1 encoding the sodium/phosphate (Na+/Pi) co-transporter Pit1 was increased in osteoblasts and osteocytes from adult Hyp mice, but not in Hyp fetal bones. The direct effects of extracellular Pi and 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] on isolated osteoblastic and osteocytic cells were also investigated. Twenty-four-hour treatment with 10-8 M 1,25(OH)2D3 increased the expression of Fgf23 in WT osteoblastic cells but not in osteocytic cells. Dmp1 expression in osteocytic cells was increased due to the 24-hour treatment with 10 mM Pi and was suppressed by 10-8 M 1,25(OH)2D3 in WT osteocytic cells. We also found the up-regulation of the genes for FGF1, FGF2, their receptors, and Egr-1 which is a target of FGF signaling, in Hyp osteocytic cells, suggesting the activation of FGF/FGFR signaling. These results implicate the complex gene dysregulation in osteoblasts and osteocytes of Hyp mice, which might contribute to the pathogenesis."xsd:string |
| http://purl.uniprot.org/citations/24710520 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0093840"xsd:string |
| http://purl.uniprot.org/citations/24710520 | http://purl.uniprot.org/core/author | "Yamazaki M."xsd:string |
| http://purl.uniprot.org/citations/24710520 | http://purl.uniprot.org/core/author | "Kawai M."xsd:string |
| http://purl.uniprot.org/citations/24710520 | http://purl.uniprot.org/core/author | "Miyagawa K."xsd:string |
| http://purl.uniprot.org/citations/24710520 | http://purl.uniprot.org/core/author | "Ohata Y."xsd:string |
| http://purl.uniprot.org/citations/24710520 | http://purl.uniprot.org/core/author | "Ozono K."xsd:string |
| http://purl.uniprot.org/citations/24710520 | http://purl.uniprot.org/core/author | "Michigami T."xsd:string |
| http://purl.uniprot.org/citations/24710520 | http://purl.uniprot.org/core/author | "Kogo M."xsd:string |
| http://purl.uniprot.org/citations/24710520 | http://purl.uniprot.org/core/author | "Nishino J."xsd:string |
| http://purl.uniprot.org/citations/24710520 | http://purl.uniprot.org/core/author | "Tachikawa K."xsd:string |
| http://purl.uniprot.org/citations/24710520 | http://purl.uniprot.org/core/author | "Koshimizu T."xsd:string |
| http://purl.uniprot.org/citations/24710520 | http://purl.uniprot.org/core/author | "Mikuni-Takagaki Y."xsd:string |
| http://purl.uniprot.org/citations/24710520 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24710520 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/24710520 | http://purl.uniprot.org/core/pages | "e93840"xsd:string |
| http://purl.uniprot.org/citations/24710520 | http://purl.uniprot.org/core/title | "Dysregulated gene expression in the primary osteoblasts and osteocytes isolated from hypophosphatemic Hyp mice."xsd:string |
| http://purl.uniprot.org/citations/24710520 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/24710520 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24710520 |
| http://purl.uniprot.org/citations/24710520 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24710520 |
| http://purl.uniprot.org/uniprot/#_E0CY01-mappedCitation-24710520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24710520 |
| http://purl.uniprot.org/uniprot/#_P70669-mappedCitation-24710520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24710520 |
| http://purl.uniprot.org/uniprot/#_Q0VBJ8-mappedCitation-24710520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24710520 |
| http://purl.uniprot.org/uniprot/#_A2ICR0-mappedCitation-24710520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24710520 |