| http://purl.uniprot.org/citations/24711449 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24711449 | http://www.w3.org/2000/01/rdf-schema#comment | "TNF-α, a pro-inflammatory cytokine, is highly expressed after being irradiated (IR) and is implicated in mediating radiobiological bystander responses (RBRs). Little is known about specific TNF receptors in regulating TNF-induced RBR in bone marrow-derived endothelial progenitor cells (BM-EPCs). Full body γ-IR WT BM-EPCs showed a biphasic response: slow decay of p-H2AX foci during the initial 24 h and increase between 24 h and 7 days post-IR, indicating a significant RBR in BM-EPCs in vivo. Individual TNF receptor (TNFR) signaling in RBR was evaluated in BM-EPCs from WT, TNFR1/p55KO, and TNFR2/p75KO mice, in vitro. Compared with WT, early RBR (1-5 h) were inhibited in p55KO and p75KO EPCs, whereas delayed RBR (3-5 days) were amplified in p55KO EPCs, suggesting a possible role for TNFR2/p75 signaling in delayed RBR. Neutralizing TNF in γ-IR conditioned media (CM) of WT and p55KO BM-EPCs largely abolished RBR in both cell types. ELISA protein profiling of WT and p55KO EPC γ-IR-CM over 5 days showed significant increases in several pro-inflammatory cytokines, including TNF-α, IL-1α (Interleukin-1 alpha), RANTES (regulated on activation, normal T cell expressed and secreted), and MCP-1. In vitro treatments with murine recombinant (rm) TNF-α and rmIL-1α, but not rmMCP-1 or rmRANTES, increased the formation of p-H2AX foci in nonirradiated p55KO EPCs. We conclude that TNF-TNFR2 signaling may induce RBR in naïve BM-EPCs and that blocking TNF-TNFR2 signaling may prevent delayed RBR in BM-EPCs, conceivably, in bone marrow milieu in general."xsd:string |
| http://purl.uniprot.org/citations/24711449 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m114.567743"xsd:string |
| http://purl.uniprot.org/citations/24711449 | http://purl.uniprot.org/core/author | "Park D."xsd:string |
| http://purl.uniprot.org/citations/24711449 | http://purl.uniprot.org/core/author | "Song J."xsd:string |
| http://purl.uniprot.org/citations/24711449 | http://purl.uniprot.org/core/author | "Yan X."xsd:string |
| http://purl.uniprot.org/citations/24711449 | http://purl.uniprot.org/core/author | "Walsh K."xsd:string |
| http://purl.uniprot.org/citations/24711449 | http://purl.uniprot.org/core/author | "Natarajan M."xsd:string |
| http://purl.uniprot.org/citations/24711449 | http://purl.uniprot.org/core/author | "Kishore R."xsd:string |
| http://purl.uniprot.org/citations/24711449 | http://purl.uniprot.org/core/author | "McDonald J.T."xsd:string |
| http://purl.uniprot.org/citations/24711449 | http://purl.uniprot.org/core/author | "Shtifman A."xsd:string |
| http://purl.uniprot.org/citations/24711449 | http://purl.uniprot.org/core/author | "Goukassian D.A."xsd:string |
| http://purl.uniprot.org/citations/24711449 | http://purl.uniprot.org/core/author | "Gee H."xsd:string |
| http://purl.uniprot.org/citations/24711449 | http://purl.uniprot.org/core/author | "Sasi S.P."xsd:string |
| http://purl.uniprot.org/citations/24711449 | http://purl.uniprot.org/core/author | "Enderling H."xsd:string |
| http://purl.uniprot.org/citations/24711449 | http://purl.uniprot.org/core/author | "Garrity B."xsd:string |
| http://purl.uniprot.org/citations/24711449 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24711449 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/24711449 | http://purl.uniprot.org/core/pages | "14178-14193"xsd:string |
| http://purl.uniprot.org/citations/24711449 | http://purl.uniprot.org/core/title | "TNF-TNFR2/p75 signaling inhibits early and increases delayed nontargeted effects in bone marrow-derived endothelial progenitor cells."xsd:string |
| http://purl.uniprot.org/citations/24711449 | http://purl.uniprot.org/core/volume | "289"xsd:string |
| http://purl.uniprot.org/citations/24711449 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24711449 |
| http://purl.uniprot.org/citations/24711449 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24711449 |
| http://purl.uniprot.org/uniprot/#_D3YXL4-mappedCitation-24711449 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24711449 |
| http://purl.uniprot.org/uniprot/#_Q0X0E6-mappedCitation-24711449 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24711449 |