| http://purl.uniprot.org/citations/24711453 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24711453 | http://www.w3.org/2000/01/rdf-schema#comment | "Triggering receptor expressed on myeloid cells 1 (TREM-1) is a superimmunoglobulin receptor expressed on myeloid cells that plays an important role in the amplification of inflammation. Recent studies suggest a role for TREM-1 in tumor-associated macrophages with relationship to tumor growth and progression. Whether the effects of TREM-1 on inflammation and tumor growth are mediated by an alteration in cell survival signaling is not known. In these studies, we show that TREM-1 knock-out macrophages exhibit an increase in apoptosis of cells in response to lipopolysaccharide (LPS) suggesting a role for TREM-1 in macrophage survival. Specific ligation of TREM-1 with monoclonal TREM-1 (mTREM-1) or overexpression of TREM-1 with adeno-TREM-1 induced B-cell lymphoma-2 (Bcl-2) with depletion of the key executioner caspase-3 prevents the cleavage of poly(ADP-ribose) polymerase. TREM-1 knock-out cells showed lack of induction of Bcl2 with an increase in caspase-3 activation in response to lipopolysaccharide. In addition overexpression of TREM-1 with adeno-TREM-1 led to an increase in mitofusins (MFN1 and MFN2) and knockdown of TREM-1 decreased the expression of mitofusins suggesting that TREM-1 contributes to the maintenance of mitochondrial integrity favoring cell survival. Investigations into potential mechanisms by which TREM-1 alters cell survival showed that TREM-1-induced Bcl-2 in an Egr2-dependent manner. Furthermore, our data shows that expression of Egr2 in response to specific ligation of TREM-1 is ERK mediated. These data for the first time provide novel mechanistic insights into the role of TREM-1 as an anti-apoptotic protein that prolongs macrophage survival."xsd:string |
| http://purl.uniprot.org/citations/24711453 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m113.536490"xsd:string |
| http://purl.uniprot.org/citations/24711453 | http://purl.uniprot.org/core/author | "Yuan Z."xsd:string |
| http://purl.uniprot.org/citations/24711453 | http://purl.uniprot.org/core/author | "Brantly M."xsd:string |
| http://purl.uniprot.org/citations/24711453 | http://purl.uniprot.org/core/author | "Colonna M."xsd:string |
| http://purl.uniprot.org/citations/24711453 | http://purl.uniprot.org/core/author | "Syed M.A."xsd:string |
| http://purl.uniprot.org/citations/24711453 | http://purl.uniprot.org/core/author | "Joo M."xsd:string |
| http://purl.uniprot.org/citations/24711453 | http://purl.uniprot.org/core/author | "Sadikot R.T."xsd:string |
| http://purl.uniprot.org/citations/24711453 | http://purl.uniprot.org/core/author | "Panchal D."xsd:string |
| http://purl.uniprot.org/citations/24711453 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24711453 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/24711453 | http://purl.uniprot.org/core/pages | "15118-15129"xsd:string |
| http://purl.uniprot.org/citations/24711453 | http://purl.uniprot.org/core/title | "Triggering receptor expressed on myeloid cells 1 (TREM-1)-mediated Bcl-2 induction prolongs macrophage survival."xsd:string |
| http://purl.uniprot.org/citations/24711453 | http://purl.uniprot.org/core/volume | "289"xsd:string |
| http://purl.uniprot.org/citations/24711453 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24711453 |
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